The Expression And Clinical Significance Of FMO2 In Ovarian Serous Cystadenocarcinoma

Objective: To study the expression and clinical significance of flavin-containing monooxygenase 2(FMO2)in ovarian serous cystadenocarcinoma.Methods: The relationship between the expression of FMO2 in ovarian cancer and the prognosis were analyzed by bioinformatics,and the FMO2-related genes and possible mechanisms were further explored by combining multiple databases.The expression of FMO2 in serous ovarian cystadenocarcinoma was verified by immunohistochemistry,and its relationship with clinicopathological factors and prognosis was analyzed.Results: The bioinformatics analysis suggests that the high expression of FMO2 predicts poor prognosis.FMO2 has a strong positive correlation with NNMT,which is related to tumor metastasis and immune invasion.FMO2 may be involved in T cell activation,leukocyte cell adhesion,leukocyte migration and extracellular matrix remodeling.Pathway analysis shows that FMO2 maybe participate in cytokine cytokine receptor interaction,chemokine pathway and PI3K-Akt signaling pathway.The high expression of FMO2 in serous ovarian cystadenocarcinoma was confirmed by immunohistochemistry,which was related to FIGO stage,omental metastasis and lymphotic metastasis and differentiation grade,but not to age,ascites volume and CA125.Among them,the more advanced the disease was,the higher the expression of FMO2 was.The expression of FMO2 has negative correlation with the prognosis,and the high expression of FMO2 predicted the poor outcome.Conclusion: FMO2 is highly expressed in serous ovarian cystadenocarcinoma.The high expression of FMO2 was associated with FIGO stage(P<0.001),omental metastasis(P=0.001),lymphatic metastasis(P=0.018)and differentiation grade(P=0.021).It is predicted that FMO2 may be associated with the development of ovarian serous cystadenocarcinoma.High expression of FMO2 may be related to poor prognosis.