The Relationship Between The Level Of Vitamin D In The Blood Of Infertile Women And The Pregnancy Outcome In Vitro Fertilization-embryo Transfer

Objective: To explore the correlation between the level of vitamin D in the blood of infertile women and the pregnancy outcome of in vitro fertilization-embryo transfer.Methods: A total of 332 infertile patients who underwent IVF-ET/ICSI fertility treatment at the Reproductive Center of Shengjing Hospital Affiliated to China Medical University and patients who underwent single blastocyst transplantation during the resuscitation cycle were selected from October 2019 to October 2020.According to the serum total 25(OH)D3 level(basic VD level)on the first visit day,it was divided into two groups: divided into vitamin D deficiency group(25(OH)D3<20ng/ml)(287 cases),vitamin D not deficiency group(25(OH)D3 ≥20ng/ml)(45 cases),according to the total serum 25(OH)D3 level(basic VD level)on the day of transplantation,they were divided into two groups: Vitamin D deficiency group(25(OH)D3<20ng/ ml)(181 cases),the vitamin D non-deficiency group(25(OH)D3 ≥20ng/ml)(151 cases),according to the transplant season,divided into spring(54 cases),summer(82 cases),autumn(117cases),four groups in winter(79 cases).To explore the effect of blood vitamin D levels in infertile women on the pregnancy outcome of in vitro fertilization-embryo transfer.Results: The total number of eggs harvested(4054),IVF fertilization rate(69.90%),ICSI fertilization rate(83.42%),and high-quality embryo rate of patients with vitamin D deficiency(25(OH)D3<20ng/ml)(287 cases)on the first visit(68.13%),high-quality blastocyst rate(45.99%)and not lack of vitamin D(25(OH)D3≥20ng/ml)(45 cases)total number of eggs harvested(579),IVF fertilization rate(72.09%),ICSI fertilization The rate(81.25%),the rate of high-quality embryos(71.32%),and the rate of high-quality blastocysts(40.93%)were not statistically significant(P>0.05).The patients were deficient in vitamin D on the day of transplantation(25(OH)D3<20ng/ ml)biochemical pregnancy rate(75.69%),clinical pregnancy rate(64.09%)and vitamin D not lacking(25(OH)D3≥20ng/ml)biochemical pregnancy rate(68.87%),clinical pregnancy rate(60.26)%)There was no statistical difference(P>0.05),the biochemical pregnancy rate(68.52%)in spring(54 cases),the clinical pregnancy rate(59.26%),the biochemical pregnancy rate in summer(82 cases)(70.73%),clinical pregnancy Rate(60.98%),biochemical pregnancy rate(75.21%)in autumn(117 cases),clinical pregnancy rate(64.10%),biochemical pregnancy rate(73.42%)in winter(79 cases),clinical pregnancy rate(63.29%)There was no statistical difference(P>0.05).Conclusion: There is no correlation between the blood vitamin D level of infertile women and the pregnancy outcome in vitro fertilization-embryo transfer.