Study On The Influence Of Cangai Volatile Oil On Physiological Indexes Related To Anxiety Of College Students

Objective: Anxiety refers to the painful experience of individual premonition of misfortune or threat,which exists universally in the population.Anxiety can develop into mental diseases such as anxiety.Cangai Volatile Oil has definite antidepressant effect,and there are many overlaps in clinical symptoms,pathogenesis and clinical treatment of depression and anxiety,so it is speculated that it can improve anxiety mood.To prove this theory,the research intends to compare three different mental arithmetic task under the condition of laboratory stress induced the difference of anxiety,and to determine the feasibility of the advantage of the higher stress method is used to study the nasal suction Cangai Volatile Oil effect on stress induced anxiety of college students,and by observing Cangai Volatile Oil after nasal inhalation of natural living condition mild anxiety of college students’ anxiety tendency index,verify its effect on the regulation of anxiety.This study will provide experimental basis for the clinical application of Cangai Volatile Oil in regulating anxiety and other adverse emotions.Methods:1.Screening of laboratory stress methods that induce anxiety:112 college students were recruited as subjects and randomly divided into 3 groups: two-digit test group(two-digit minus two-digit)with 30 cases,three-digit test group(three-digit continuous minus 17 cases)with 49 cases and four-digit test group(four-digit addition and subtraction method)with 33 cases,the corresponding mental arithmetic tasks were completed in the stress period,and the low frequency high frequency ratio(LF/HF)of heart rate variability(LF/HF)in the baseline period and the stress period were evaluated,and compared between and within the groups.2.Study on the influence of Cangai Volatile Oil on physiological indexes related to anxiety under laboratory stress condition of college students:108 college students who met the inclusion criteria were re-selected and randomly divided into CAVO group,Cinnamomum camphora leaf oil group and blank group(36 cases/group).All the subjects in each group were induced by "3-digit continuous reduction of 17" mental arithmetic stress to induce anxiety.After the elimination of those who did not respond to stress,there was no statistical difference in the anxiety-related indexes of the three groups at baseline,and they were equalized and comparable.After the anxiety was induced under laboratory stress conditions,30 cases of Cinnamomum camphora leaf oil group,30 cases of CAVO group,and 31 cases of blank group were inhaled Cinnamomum camphora leaf oil and Cangai Volatile Oil respectively,while the blank group had no essential oil intervention.The total number of heart beats,systolic blood pressure(SBP),diastolic blood pressure(DBP)and LF/HF in the baseline period,stress period,intervention period and recovery period of the trial were measured,and the comparison was made between and within the parallel groups.3.Study on the influence of Cangai Volatile Oil on anxiety tendency index of mild anxiety college students: Forty-two subjects assessed as mild anxiety by SAS were re-selected and randomly divided into CAVO group and blank group(21 cases/group).The multifunctional combined monitor was used to collect the EEG signals,and the anxiety tendency index was calculated after the EEG analysis software package was processed by wavelet algorithm,to observe the change of anxiety tendency index of each subject after inhalation of Cangai Volatile Oil through nose.Results:1.Identification of laboratory stress methods that induce anxiety:there was no difference in LF/HF among the three groups at baseline(P > 0.05),LF/HF stress period in the three-digit test group was significantly higher than that in the baseline period(P < 0.05),and there was no difference in LF/HF stress period and baseline period between the two-digit test group and the four-digit test group(P > 0.05).Therefore,a three-digit mental arithmetic task with a continuous reduction of 17 was selected as the laboratory stress method to induce anxiety.2.Effects of Cangai Volatile Oil on physiological indices related to anxiety under laboratory stress condition of college students: comparison between stress period and baseline period:LF/HF,total number of heart beats,SBP and DBP in stress period were higher than those in baseline period(P < 0.05),and there was no difference in the above indexes between baseline period and stress period(P > 0.05).Comparison of intervention period and stress period:LF/HF,total number of heart beats,SBP and DBP in blank group were not significantly different between intervention period and self-stress period(P >0.05).LF/HF,total number of heart beats,SBP and DBP in CAVO group during intervention period were lower than those in self-stress period(P < 0.05),and there were no significant differences between CAVO group and baseline period and recovery period(P > 0.05).LF/HF,SBP and DBP in Cinnamomum camphora leaf oil group during intervention period were lower than those in the self-stress period(P < 0.05),higher than those in the baseline period and recovery period(P < 0.05),but the total number of heart beats in the intervention period had no significant change compared with that in the stress period(P > 0.05).Comparison between the groups found that,the intervention period of LF/HF and SBP in CAVO group was lower than that in the other two groups,and DBP was lower than that in the blank group(P < 0.05).3.Influence of Cangai Volatile Oil on anxiety propensity index of mild anxiety college students: before intervention,there was no difference in the anxiety tendency index between the CAVO group and the blank group(P > 0.05).The anxiety tendency index of CAVO group after intervention was significantly lower than that before intervention(P <0.05),and lower than that of blank group(P < 0.05),and there was no difference in anxiety tendency index measured by EEG before and after intervention in blank group(P > 0.05).Conclusion:Under laboratory stress conditions,physiological indexes related to anxiety were significantly decreased after inhalation of Cangai Volatile Oil,which indicated that Cangai Volatile Oil could relieve anxiety after stress.At the same time,Cangai Volatile Oil can also reduce the anxiety tendency index of college students with mild anxiety after inhalation,indicating that it may relieve the anxiety of college students under the natural life state.