Construction Of Cerebrovascular Atlas And Its Application In Quantitative Analysis For Moyamoya Disease

The middle cerebral artery(MCA)is one of the main blood supply arteries of the brain.The blood supply area covers most of the cerebral cortex and basal ganglia.MCA occlusion accounts for 79.6% of occlusive cerebrovascular diseases.Symptomatic patients can be treated with various methods,including intracranial angioplasty,stent implantation and cerebrovascular bypass surgery.Quantitative analysis of cerebral blood flow is of great significance in the treatment of ischemic stroke.At present,the treatment of occlusive cerebrovascular disease is mostly based on surgical treatment.The superficial temporal artery-middle cerebral artery anastomosis(STA-MCA)is one of the most commonly used surgical treatments for occlusive cerebrovascular disease.Direct revascularization is likely to cause syndrome such as cerebral hemorrhage,stroke,aphasia,and cognitive decline.The pathological changes of cerebral hemodynamics in patients with cerebrovascular disease are very complicated and changeable,and doctors often need to follow up,detect and quantify the patients multiple times.Neuroimaging can directly describe or indirectly observe the brain tissue,vascular structure and cerebral blood perfusion.It is an important tool for doctors to diagnose cerebrovascular disease.At present,there are three main problems in the study of cerebrovascular diseases based on magnetic resonance imaging technology.First,the gold standard for the quantification of human cerebral hemodynamic parameters,Positron Emission Tomography(PET)and single photon emission computerization Single Photon Emission Computed Tomography(SPECT)has a certain degree of radioactivity,and the operating procedures is complicated,so it is not suitable for multiple follow-up imaging.Second,for the important arterial blood vessels of the human brain that affect cerebrovascular diseases,experienced physicians have to manually divide the Region of Interest(ROI).This method has a certain degree of subjectivity,the efficiency of division is low and the granularity of division is insufficient,and it is unable to finely segment many important functional brain areas in the MCA drainage area.Third,the current study lacks the analysis of the corresponding relationship between ROI perfusion and postoperative cognitive decline.For the above-mentioned medical problems,this article first uses Magnetic Resonance Angiography(MRA)to enhance and extract the MCA,and merge it with T1-weighted imaging to demonstrate the perfusion distribution of the MCA in the brain;then,use T1-weighted imaging and Arterial Spin Labeling(ASL)imaging complete the fine segmentation of important functional brain areas in the middle artery watershed,and accurately quantifies the changes in brain perfusion after moyamoya vascular reconstruction surgery;finally,the resting state is used Resting-state functional Magnetic Resonance Imaging(rs-f MRI)uses functional connection number entropy to dynamically measure the temporal and spatial dimensions of the moyamoya brain network to further explore neuroimaging features related to postoperative complications.In this paper,the fusion of multimodal magnetic resonance imaging has been successfully applied to the prognosis assessment of cerebrovascular disease,which reflects its clinical value as an auxiliary diagnosis of cerebrovascular disease.