The Association Between Arterial Stiffness And Diabetes

Objective To explore the association between arterial stiffness and diabetes.Methods In this prospective cohort,we included 26360 participants who participat ed in at least one survey in 2010-2011,2012-2013,or 2014-2015,and consented to participate in brachial-ankle pulse wave velocity(baPWV)examination.We exclud ed individuals who did not participated follow-up surveys,those with history of dia betes,cardiovascular disease,or chronic kidney disease and incomplete information.Included were 14159 participants.Normal arterial stiffness was defined as baPWV<1400cm/s;the borderline was 1400≤baPWV<1800cm/s;and the elevated was baPW V≥1800cm/s.Cox proportional hazard regression model was used to estimate hazard ratios(HRs)and 95% confidence intervals(CIs)of incident diabetes.FBG and baPWV were repeatedly measured at baseline and follow-ups.Path analysis was used to analyze the temporal causal relationship between baPWV and FBG,among 8956 participants with repeated assessment of baPWV and FBG twice in 2010-2017.Results The study population had a mean age of 48.3±12.0 years at the baseline,and 65.2% were men.During a mean 3.72 years of follow-up,we documented 979 new diabetes.The cumulative incidence of diabetes was 6.91%.Compared to the n ormal group,HR(95%CI)for incident diabetes was 1.59(95%CI: 1.34-1.88)for th e borderline group,and 2.11(95%CI: 1.71-2.61)for the elevated group,after adjust ing for confounders.Mean follow-up time was 4.53 years in the path analysis.In t he fully-adjusted model,the standardized correlation coefficient of baseline baPWV and follow-up FBG(β2)was 0.09(95%CI: 0.05-0.10,P=0.01),whereas the standard ized correlation coefficient of baseline FBG and follow-up baPWV(β1)was 0.00(95%CI:-0.02-0.02;P=0.50),which was significantly less than β2(P<0.01).Conclusions Arterial stiffness,as measured by baPWV,was associated with risk of developing diabetes.Arterial stiffness appeared to precede the increase in FBG.Figure 5;Table 11;Reference 99...