| Objectives To investigate the relationship between fasting blood glucose level（FBG）and arterial stiffness in non-diabetic population.Methods Based on the Kailuan study cohort,the individuals who completed two tests of brachial-ankle pulse wave velocity（ba PWV）from October 2010 to December 2020 and were non-diabetic at the first ba PWV testing were selected.Multiple linear regression was applied to explore the impact of baseline FBG level on the follow-up ba PWV and its progress during follow-up,and a stratified analysis by age,sex,blood pressure and body mass index will be made.Moreover,a sensitivity analysis performed by excluding the participants who were onset of diabetes or used the treatment of lipid-lowering drugs.Results 18899[11786 males（62.36%）]subjects met the inclusion criteria.At baseline,the average age（the first ba PWV measurement）was（46.82±11.73）years old and the average ba PWV was（1439.30±307.22）cm·s-1.At the follow-up end（the second ba PWV measurement）,the average age was（50.91±12.02）years old,and the average ba PWV was（1499.52±333.69）cm·s-1.After adjusted for other confounding factors,the multiple linear regression analysis showed that an increase of 1 mmol·L-1in baseline FBG resulted in an increase of 13.02 cm·s-1in ba PWV at the end of follow up.And an increase of 1 mmol·L-1in FBG during follow-up period resulted in an increase of 9.52 cm·s-1at the end of follow up,6.80 cm·s-1in progression of ba PWV,respectively.However,there were no positive correlation between baseline FBG and ba PWV progression during follow-up.The stratified analysis and sensitivity analysis were the same as the main analysis.Conclusions In non-diabetic population,baseline FBG is related to the follow-up arterial stiffness but not to the progression of arterial stiffness during the follow-up period.Elevated FBG level during the follow-up period is a factor that affected the progression of arterial stiffness.Figure 0;Table 7;Reference 158... |
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