| Objective: Lumbar disc herniation is common and frequent in clinical practice.With the development of society and technology,the incidence rate of this disease has been increasing rapidly year by year.The age of onset has been decreasing year by year,showing a trend of younger age.Duhuo Jisheng decoction is widely used in clinical practice.Therefore,this study discusses the clinical efficacy and safety evaluation of Duhuo Jisheng Decoction on lumbar disc herniation of liver and kidney deficiency type.Methods: The patients in the Department of orthopedics and traumatology of huayuanshan Hospital of Hubei Provincial Hospital of traditional Chinese medicine from August 2020 to June 2021 were retrospectively analyzed.The basic information,duration of disease,total length of hospital stay and follow-up were collected.According to the inclusion and exclusion criteria,80 patients with lumbar disc herniation diagnosed as liver and kidney deficiency were included.The patients were divided into two groups according to different treatment schemes,with 40 cases in each group.The control group was treated with routine treatment,such as oral non steroidal drugs for analgesia,continuous intravenous drip of mannitol for 3 days to improve circulation and symptomatic treatment for dehydration,oral Panlong seven tablets to activate blood circulation,remove blood stasis and dredge collaterals,supplemented by traditional Chinese medicine characteristic physiotherapy to relax tendons and dredge collaterals,activate blood circulation and relieve pain.The treatment group was treated with Duhuojisheng Decoction on the basis of the control group,with a course of 7 days and four courses of continuous observation.The VAS score,modified Oswestry index score and TCM syndrome score of the two groups before and after treatment were analyzed and compared,using SPSS25.0 make statistical analysis on the data to evaluate the efficacy and clinical safety.Results: 1.General data: there are some differences in the general data between the two groups.According to statistical analysis（P > 0.05）,it is suggested that the data of the two groups have comparative value.2.VAS score: before treatment,the VAS score of the control group was（5.88 ± 1.83）and that of the treatment group was（6.25 ± 1.55）.There was a comparative value between the two groups（t = 0.990,P = 0.325 > 0.05）.After one week of treatment,the VAS score of the treatment group was（5.63 ± 1.17）and that of the control group was（5.35 ± 1.46）.Statistical analysis showed that there was no significant difference between the groups（t = 0.930,P = 0.355 > 0.05）.After 2 weeks of treatment,the VAS score of the treatment group was（4.25 ± 0.74）and that of the control group was（4.70 ± 1.09）.Statistical analysis showed that there was significant difference between the groups（t = 2.157,P = 0.034 < 0.05）.After 4 weeks of treatment,the VAS score of the treatment group was（2.58 ± 0.81）and that of the control group was（3.78 ± 1.07）.Statistical analysis showed that there was significant difference between the groups（t = 5.635,P = 0.000 < 0.05）.3.ODI index: before treatment,the ODI index of the control group was（36.18 ± 4.41）and that of the treatment group was（36.25 ± 3.90）.There was a comparative value between the two groups（t = 0.081,P = 0.936 > 0.05）.One week after treatment,the ODI index of the treatment group was（34.78 ± 3.31）and that of the control group was（34.65 ± 3.72）.Statistical analysis showed that there was no significant difference between the groups（t = 0.159,P = 0.874 > 0.05）.After 2 weeks of treatment,the ODI index of the treatment group was（29.45 ± 2.61）and that of the control group was（31.50 ± 2.64）.Statistical analysis showed that there was significant difference between the groups（t = 3.491,P = 0.001 < 0.05）.After 4 weeks of treatment,the ODI index of the treatment group was（20.65 ± 2.26）and that of the control group was（24.65 ± 1.42）.Statistical analysis showed that there was significant difference between the groups（t = 9.472,P = 0.000 < 0.05）.4.TCM syndrome score: before treatment,the score value of the control group was（7.25 ± 2.33）and that of the treatment group was（7.32 ± 2.20）.There was a comparative value between the two groups（t = 0.148,P = 0.883 > 0.05）.After one week of treatment,the score of the treatment group was（6.73 ± 1.83）and that of the control group was（6.70 ± 1.88）.Statistical test showed that there was no significant difference between the two groups（t = 0.060,P = 0.952 > 0.05）.After 2 weeks of treatment,the score of the treatment group was（4.93 ± 1.07）and that of the control group was（5.53 ± 1.30）.Statistical test showed that there was significant difference between the two groups（t = 2.252,P = 0.027 < 0.05）.After 4 weeks of treatment,the score of the treatment group was（3.60 ± 0.50）and that of the control group was（4.05 ± 0.68）.Statistical test showed that there was significant difference between the two groups（t = 3.389,P = 0.001 < 0.05）.Conslusion: 1.Duhuo Jisheng decoction can significantly alleviate the clinical symptoms of patients with liver and kidney deficiency type lumbar disc herniation（LDH）;2.Duhuo Jisheng decoction can significantly improve the symptoms of waist and knee soreness,pain and fatigue,limb numbness and so on caused by LDH of liver and kidney deficiency,significantly reduce the score of traditional Chinese medicine syndrome,and gradually restore lumbar function,which is conducive to rehabilitation treatment.3.Duhuojisheng decoction has a low incidence of gastrointestinal adverse reactions in the treatment of lumbar disc herniation of liver and kidney deficiency type,and its clinical application is safe. |
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