Study On The Correlation Between Plasma Homocysteine Level And Parkinson’s Disease

ObjectiveTo study the relationship between plasma homocysteine(Hcy)levels and Parkinson’s disease(PD),and to explore the correlation between plasma homocysteine levels and the course of Parkinson’s disease,disease progression,motor disorders and age in patients with Parkinson’s disease.To provide better intervention and treatment for Parkinson’s disease.MethodThe plasma levels of Hcy were compared between 94 patients with Parkinson’s disease and 95 healthy controls.According to modified Hoehn and Yahr stages and different course of disease,the patients in Parkinson’s disease group were divided into two groups,and the difference of blood Hcy level between the above groups was compared.Unified Parkinson Disease Rating Scale III(UPDRSIII)was used to evaluate the motor impairment of Parkinson’s disease patients.Pearson correlation analysis was used to analyze the correlation between blood Hcy and motor impairment and age in Parkinson’s disease group.Statistical software SPSS25.0 is used for statistical analysis.ResultCompared with the control group,the plasma Hcy level in the PD group was significantly higher than that in the control group(P<0.05).There was no significant difference between the level of Hcy in PD patients and the course of disease(P>0.05),and between the level of Hcy and the progression of disease(P<0.05).Blood Hcy was positively correlated with UPDRSIII score and age in PD group(r = 0.417,P <0.05),(r = 0.207,P <0.05).ConclusionHigh levels of Cy are associated with disease progression,dyskinesia and age in patients with Parkinson’s disease,and are risk factors for Parkinson’s disease progression.