Survival Analysis Of Clinical Characteristics And TCM Syndromes Of 151 Patients With Motor Neuron Disease

objectives : We retrospectively analyzed the clinical features of motor neuron disease(MND)in the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine and explored the clinical features on patients survival.Methods : Collect the patients with motor neuron disease who were hospitalized in the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from September 2013 to January 2021,and count the patients’ age of onset,diagnostic delay,onset site,diagnosis classification,diagnosis type,and whether there are comorbidities,Whether to use riluzole and edaravone,whether it is combined with important comorbidities,TCM syndrome differentiation and other characteristics.The survival status of patients was followed up by telephone,and single-factor and multi-factor survival analysis were performed on MND patients with different clinical characteristicsResults: 1.151 patients with MND were included in this study.There was no statistically significant difference in age of onset in gender,diagnostic classification and diagnostic type(P >0.05).The median diagnostic delay of MND was 12 months.There was no statistically significant difference in the diagnosis delay time between men and women.At the diagnosis Classification(9 months for definite diagnosis vs.28 months for probable diagnosis vs.16 months for possible diagnosis,p=0.001)and diagnosis type(Amyotrophic lateral sclerosis 12 months VS.Primary lateral sclerosis 60 months VS.Progressive muscular atrophy10 months VS.Progressive bulbar palsy 8 months,p=0.04)The difference was statistically significant.2.151 cases were classified by TCM syndrome differentiation,32 cases of Qi deficiency and blood stasis(21.2%);61 cases of liver and kidney deficiency(40.4%);11 cases of damp-heat immersion(7.3%);19 cases of spleen and kidney deficiency(12.6%));19 cases of spleen and stomach weakness(12.6%);9 cases of phlegm and blood stasis(6.0%).3.Survival analysis of 112 patients with MND,diagnostic delay and age of onset were risk factors for death in MND patients(P<0.05).Survival analysis of 67 patients with amyotrophic lateral sclerosis found that the diagnostic delay and age of onset were risk factors for death(P<0.05),while for 28 patients with progressive muscle atrophy,only the diagnostic delay was the death of the patient Risk factors(P<0.05).Conclusions: The diagnostic delay of patients with confirmed patients is shorter than that of suspected and probable patients,and the diagnostic delay of patients with progressive bulbar palsy is shorter than that of other types of patients.Survival analysis found that diagnostic delay and age of onset were risk factors for death in patients with MND.Survival analysis of patients with amyotrophic lateral sclerosis and progressive muscular atrophy respectively found that diagnostic delay and age of onset were deaths for the patients,for the patients with progressive muscle atrophy,only the diagnostic delay is a risk factor for death.The TCM syndromes of MND patients are mainly divided into six types:Qi deficiency and blood stasis syndrome,liver and kidney deficiency syndrome,damp-heat immersion syndrome,spleen and kidney deficiency syndrome,spleen and stomach weakness syndrome,and phlegm and blood stasis syndrome.