| Objective:By observing the differences of microcirculation in macular area of subjects with different heights of myopia,including vascular length density(VLD),vascular perfusion density(VPD),area,circumference and morphological index of non-cavity and non-perfusion area(FAZ)in macular area,the microcirculation in macular area of subjects with different heights of myopia was studied.Combined with traditional Chinese medicine dialectical classification,the differences between retinal blood flow density and the morphology of fovea non-perfusion area in patients with different TCM syndromes of high myopia were analyzed.Through the research of high myopia patients with macular Gong Huan damage and provides an objective quantitative measurement of retinal capillary damage,understand the differences between each kind of this syndrome,in the future in terms of high myopia prevention,by TCM(traditional Chinese medicine,acupuncture and moxibustion,etc.)and western medicine intervention,protect vision,delay,and the objective assessment of prognosis,it is high myopia eyes provide evidence for early prevention of complications.Methods: Prospective analysis was performed in this study.Statistical analysis was performed on patients who met the diagnostic criteria for refractive errors admitted to Yinhai Hospital of Chengdu University of Traditional Chinese Medicine from August 2020 to April 2021.According to the high myopia,the patients were divided into simple high myopia group and pathological high myopia group.The right eye was taken from all the patients to complete the relevant study.The TCM syndrome type scale was used to carry out TCM dialectical classification of the subjects,and the superficial retinal blood flow density in the macular area,the area,circumference and morphological index of the vascularless area in the fovea were measured by Zeis Cirrus5000 OCTA.Result: A total of 82 subjects with high myopia aged between 18 and 40 years were included in this study,2 of whom were excluded from the group due to unsatisfactory data extraction in the later period,including 50 in the simple high myopia group and 30 in the pathological high myopia group.1.The gender composition of the simple high myopia group and the pathological high myopia group were 50 patients,including 22 males and 28 females,respectively.There were 30 patients in pathological high myopia group,including 14 males and 16 females,and there was no significant difference in sex composition between the two groups(P > 0.05).2.Comparison of TCM syndromes distribution between the simple high myopia group and the pathological high myopia group,including 50 patients in the simple high myopia group,including 24 patients with deficiency of liver and kidney syndrome;26 patients with Qi and blood deficiency syndrome;30 patients in pathological high myopia group,including 15 patients with deficiency syndrome of liver and kidney;15 patients with Qi and blood deficiency syndrome;There was no significant difference in syndromes between the two groups(P <0.05).3.Among the 50 patients with simple high myopia,the average diopter of 22 male patients was(-8.20±1.53)D;The average refraction of 28 female patients was(-7.71±1.30)D.VLD and VPD(10.78±4.31,20.68±2.16,19.55±2.14,0.18±0.08,0.36±0.04,0.34±0.04mm·mm-2)in the central macular area,the inner macular area and the whole area of male patients were compared with that of female patients(9.55±3.92,21.25±1.64,20.08±1.73,0.15±0.07,0.37±0.03,0.34±0.03 mm·mm-2),and there was no statistical significance(all P > 0.05).4.Among the 50 cases of simple high myopia group,there were 24 cases of deficiency of liver and kidney and 26 cases of deficiency of qi and blood.Comparison of related parameters of macular VLD,VPD and FAZ among patients with different TCM syndrome types showed no statistical significance(P > 0.05).5.Among the 30 patients in the pathological high myopia group,there were 15 cases of liver and kidney deficiency syndrome and 15 cases of Qi and blood deficiency syndrome.There was no statistical significance in the comparison of VLD,VPD and FAZ related parameters in the central area of macular area among patients with different TCM syndrome types(P > 0.05),but there were significant differences in VLD and VPD in the inner area of macular area and the whole area(P > 0.05).6.The VLD in the central area of macula was 10.09±4.10 in the simple myopia group and the pathological high myopia group,respectively;10.49±3.65mm·mm-2),there was no significant difference(P > 0.05);VLD in the inner layer of macula were(21.00 ± 1.89;14.95 ± 1.99),VLD of macular whole area was 19.84 ± 1.92,respectively;14.14±1.97mm·mm-2)was significantly different(P > 0.05);VPD in the central area of macular area between the two groups was(0.17±0.07;0.16±0.03mm·mm-2),there was no statistical significance(P > 0.05 for all);VPD in the inner layer of macula were(0.37±0.03;0.30±0.04)and VPD in the macular region were 0.34±0.03,respectively;0.28±0.04mm·mm-2)was significantly different(P >0.05);And there were no significant differences in FAZ area,circumference and plumpness of macular area between the two groups(P > 0.05).7.There was no correlation between the age of patients with simple high myopia and superficial VLD and VPD in the macular area as a whole,in the center and in the inner layer.There was no correlation between age and the area,circumference and plumpness of FAZ.Conclusion:1.There was no significant difference in VLD,VPD and FAZ area,perimeter and fullness of macular area between simple high myopia group and gender or age group.2.There were no significant changes in retinal vascular density,macular FAZ area,perimeter and fullness in different TCM Syndromes of simple high myopia.3.There were differences in retinal vascular density among different TCM Syndromes of pathological high myopia.The deficiency of liver and kidney in the inner layer of macular area and the whole area was significantly lower than that in the deficiency of Qi and blood;Therefore,in the clinical process,we can predict the progress of different patients by TCM syndrome types,so as to prevent.4.With the development of simple pathological high myopia,the retinal vascular density in the inner layer and the whole macular area decreased gradually,but there was no significant difference in the retinal vascular density in the central macular area and the area,perimeter and fullness of FAZ in the macular area. |
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