The Effects Of Limb Remote Ischemic Conditioning On Neurological Function And Serum IL-6 And MMP-9 In Patients With Acute Cerebral Infarction

Objective To observe the effects of limb remote ischemic conditioning（RIC）treatment on neurological function score and serum interleukin-6（IL-6）and matrix metalloproteinase-9（MMP-9）in patients with acute cerebral infarction（ACI）,and explore the effect of RIC therapy on neurological recovery in ACI patients and its possible brain protection mechanism.Methods A total of 140 patients with acute cerebral infarction admitted to the Department of Neurology of the Affiliated Central Hospital of Shenyang Medical College from December 2020 to January 2,2022 were selected as research subjects and divided into 70 cases in experimental group and 70 cases in control group according to random numbers.In the control group,the patients were given standard treatments such as improving cerebral blood supply,nourishing nerves,antiplatelet aggregation,lowering intracerebral pressure,lowering lipids and stabilizing plaque according to the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018.Experimental group: In addition to the control group,ischaemic adaptation（RIC）treatment was given to the distal limb site for 12± 2 days.Patients in both groups were scored on the National Institutes of Health Neurological Deficit Scale（NIHSS） on admission day 1,12±2 days,and follow-up on day 90±7.Patients in both groups were scored on the Modified Rankin Scale（m RS）on admission day 1and follow-up on day 90 ± 7.The levels of serum interleukin-6（IL-6）and matrix metalloproteinase 9（MMP-9）were measured on day 1 and 12 ± 2 of admission in both groups.For the data obtained from the experiment,SPSS26.0software was used for statistical analysis.Results1.There was no significant difference in NIHSS scores on the first day of admission between the two groups（P>0.05）,the NIHSS scores of the two groups were reduced at the follow-up of day 12±2,90±7 days,compared with day 1,and the difference was statistically significant（P 0.05）,and the m RS scores of the two groups decreased compared with the first day at the follow-up on days90±7,and the difference was significant（P<0.01）,and the experimental group was significantly different from the control group（P<0.01）.3.There was no significant difference in the levels of IL-6 and MMP-9 between the two groups on the first day of admission（P> 0.05）.After treatment,the levels of IL-6 and MMP-9 in the two groups were significantly lower than those on the first day（P< 0.01）,compared with the control group,there was significant difference（P< 0.01）in the levels of the above-mentioned serum indexes in the experimental group after treatment.4.During the operation of the experimental group,32 patients reported pain in the compressed limbs,and 3 patients had subcutaneous petechiae in the compressed limbs,but the symptoms completely disappeared before the next treatment.Conclusions Limb remote ischemic conditioning can reduce NIHSS scores and m RS scores,alleviate neurological deficits,and improve the prognosis of ACI patients.RIC treatment can reduce the serum levels of IL-6 and MMP-9indicators,suggesting that RIC may play a cerebral protective role by reducing the inflammatory response and preventing the aggravation of blood-brain barrier disruption.RIC treatment has high compliance and no serious adverse effects,which is a safe and effective treatment method for ACI and is worth promotion.