Clinical Significance Of Serum Prealbumin And Plasma Fibrinogen In Early Diagnosis Of Kawasaki Disease

Objective Kawasaki disease is also known as cutaneous mucosal lymph node syndrome.In recent years,according to the epidemiological survey results of various provinces in China,the incidence of Kawasaki disease has been increasing year by year,and has become the main cause of children’s acquired heart disease,which significantly affects the occurrence of long-term heart disease in adults.The diagnosis of Kawasaki disease mainly depends on clinical manifestations.In recent years,whether laboratory indicators can provide reference value in the early diagnosis of Kawasaki disease has become one of the research hotspots.In this study,we investigated whether serum prealbumin and plasma fibrinogen have certain reference value in the early diagnosis of Kawasaki disease and whether they can predict kawasaki disease complicated with coronary artery injury,in order to provide reference and suggestions for clinicians in the early diagnosis of Kawasaki disease.Methods A retrospective analysis of collected in September 2018 to December 2021 in the children’s hospital of shenyang medical hospital treatment of 80 cases of children with kawasaki disease,through the heart colour to exceed examination results are divided into 9 cases of coronary artery lesion group and 71 cases of coronary artery damage group,at the same time selection during the same period with our hospital respiratory infectious fever in 60 cases as respiratory infectious fever group,Sixty healthy children underwent physical examination in the child health care department as healthy control group.The pre-albumin and fibrinogen levels and relevant clinical data of the subjects were collected,and relevant statistical analysis was conducted by the above groups.Results一.Analysis results of serum Vit K2 levels in 1732 children:1.Analysis of the Levels of Serum Prealbumin and Plasma Fibrinogen in Kawasaki Disease Group,Respiratory Infection Fever Group and Healthy Control Group There was no significant difference in age and gender among the three groups（P > 0.05）.（1）The level of serum prealbumin in Kawasaki disease group was lower than that in respiratory infection fever group and healthy control group.The level of fibrinogen in plasma was significantly higher than that in respiratory infection fever group and healthy control group（P < 0.05）.（2）The serum prealbumin and plasma fibrinogen of Kawasaki disease group,respiratory infectious fever group and healthy control group were analyzed by binary Logistic regression analysis.The levels of serum prealbumin and plasma fibrinogen in patients with respiratory infection fever and healthy control group were significantly different from those in KD group（P < 0.05）.（3）The AUC of serum prealbumin,plasma fibrinogen and their combination were0.831,0.898 and 0.915,respectively.The cut-off value of serum prealbumin was 12.5mg/d L,the sensitivity was 78.8% and the specificity was 76.7%.The cut-off value of fibrinogen was 3.415 g/L,the sensitivity was 93.8% and the specificity was 77.5%.The sensitivity of the combined index was 91.3% and the specificity was 83.3%.It was found that the combined indicator AUC was higher and the sensitivity and specificity were better.2.Analysis results of serum prealbumin and plasma fibrinogen levels in coronary artery injury group and non-coronary injury group.There was no significant difference in age and gender between the two groups（P >0.05）.There was no significant difference in serum prealbumin and plasma fibrinogen between the two groups（P > 0.05）.Conclusions1.The changes of acute phase serum prealbumin and plasma fibrinogen levels in children with Kawasaki disease have some reference value for early diagnosis of Kawaki disease.2.Serum prealbumin and plasma fibrinogen may not predict coronary injury in Kawasaki disease.