Study On The Association Between Sedentary Behavior And Multiple Chronic Metabolic Diseases

Aims:In recent years,common metabolic diseases have become key diseases endangering the lives and health of people all over the world,in addition to infectious diseases.At the same time,sedentary behavior in the population is increasing,and sedentary behavior is closely related to a variety of chronic diseases or their risk factors.That in this study we explored the relationship between sedentary behavior and four chronic metabolic diseases(hypertension,diabetes,hyperlipidemia and metabolic syndrome),so as to provide a theoretical basis for guiding people to reduce sedentary behavior and prevent chronic metabolic diseases.Methods:The data of this study based on 14133 respondents aged≥20 years in the National Health and Nutrition Examination Survey(NHANES)from 2011 to 2016.The required research variables were obtained through questionnaire or laboratory examination.The definition of four metabolic diseases(including pre-hypertension,stage 1 hypertension,stage 2 hypertension,pre-diabetes,diabetes,hyperlipidemia and metabolic syndrome)were determined by obtaining the required research data through questionnaires or laboratory examinations.Sedentary behavior was divided into average daily total sedentary time(<3h,3-5.9h and≥6h),watching TV time(<2h,≥2h)and using computer during leisure time(<1h,≥1h).The data description and statistical analysis of this study were based on complex weighting.Categorical variables were statistically described by frequency and constituent ratio,and Rao Scott-c~2 was used to test the statistical difference.Through logistic regression analysis,three models were constructed,in which model 1 only adjusted sedentary behavior variables;Model 2further adjusted for gender,age,race,education and income;The variables adjusted by model 3 include the variables in model 2,as well as smoking status,sports and BMI.The obtained odds ratio(OR)and 95%CI(confidence interval,CI)were used to express the correlation between sedentary behavior with four chronic metabolic diseases.IBM SPSS Statistics 24.0 software was used for statistical analysis.When P<0.05,it was considered that the statistical difference was significant.Results:1.From 2011 to 2016,66.8%of American adults watching TV for more than 2hours a day;49.6%of them using computers during leisure time for more than one hour;The total sedentary time per day was more than 6 hours,accounting for 57.9%.2.The results of population-wide multivariate adjusted model analysis showed that compared with American adults who watching TV<2h would increase the risk of pre-hypertension,stage 1 hypertension,diabetes and hyperlipidemia,with OR(95%CI)of 1.195(1.062,1.343),1.620(1.413,1.896),1.309(1.115,1.537)and 1.190(1.064,1.331);No association was found between watching TV time with the risk of stage 2hypertension,pre-diabetes and metabolic syndrome.In addition,the time of using computer in leisure time with the risk of four metabolic diseases were not statistically significant.Compared with those with total sedentary time<3h,those with total sedentary time of 3-5.9h per day would increase the risk of pre-hypertension,and those with total sedentary time≥6h would increase the risk of hyperlipidemia,with OR(95%CI)of 1.201(1.018,1.417)and 1.266(1.049,1.527)respectively.3.In the multivariate adjusted model analysis results of different characteristic populations,compared with the same category of lower daily sedentary behavior,among men,watching TV≥2h a day would increase the risk of pre-hypertension and stage 1 hypertension;The total sedentary time 3-5.9h would increase the risk of pre-hypertension.Among women,watching TV≥2h would increase the risk of stage 1hypertension,diabetes and hyperlipidemia.Young people:watching TV≥2h would increase the risk of pre-hypertension,stage 1 hypertension and metabolic syndrome;The total sedentary time 3-5.9h would increase the risk of pre-hypertension.Middle aged people:watching TV≥2h would increase the risk of stage 1 hypertension,diabetes and hyperlipidemia;Total sedentary time≥6h would increase the risk of hyperlipidemia.Elderly population:Total sedentary time≥6h would increase the risk of hyperlipidemia.Normal BMI population:Watching TV≥2h would increase the risk of diabetes and hyperlipidemia;Total sedentary time≥6h would increase the risk of hyperlipidemia.Overweight population:Watching TV≥2h would increase the risk of pre-hypertension and stage 1 hypertension;The total sedentary time 3-5.9h would increase the risk of hyperlipidemia.In the obese population:Watching TV≥2h would increase the risk of stage 1 hypertension and hyperlipidemia;Using computer during leisure time≥1h would increase the risk of stage 1 hypertension;The total sedentary time 3-5.9h would increase the risk of pre-hypertension.Conclusions:1.From 2011 to 2016,the daily of watching TV and total sedentary time of American adults were at a high level;2.American adults watching TV for≥2 hours or total sedentary time≥3 hours will increase the risk of pre-hypertension/stage 1 hypertension,diabetes and hyperlipidemia.3.Women and middle-aged people watching TV for a long time(≥2 hours)will increase the risk of stage 1 hypertension,diabetes and hyperlipidemia;young people watching TV for≥2 hours will increase the risk of metabolic syndrome.4.Overweight or obese people watching TV for≥2 hours or total sedentary time≥3 hours will increase the risk of pre-hypertension/stage 1 hypertension and hyperlipidemia.