Correlation Between Breast Feeding And Breast Cancer And Its Classification

BackgroundBreast cancer has become the most common malignant tumor of women all over the world,and it has also caused a serious impact on women’s health.China’s population ranks in the forefront of the world,and the incidence of breast cancer is increasing year by year.Breast cancer is a disease with different molecular types and different risk factors,and different risk factors have different effects on different molecular types of breast cancer.The influence factors of breastfeeding,as a kind of easy to change and influence between different subtypes of breast cancer and breast cancer are not entirely clear,we need to further explore and discover,especially after the open three one-child policy,to promote women to breastfeed and provide data support to extend the time of feeding behavior.Materials and MethodsWe collected 339 cases of breast cancer patients in the Department of Breast Surgery,the Second Hospital of Jilin University and 458 cases of people who were not diagnosed with breast cancer by breast screening clinic,and counted the related factors of common breast cancer,especially the data related to breastfeeding.The relationship between breast feeding and breast cancer and its different molecular subtypes was analyzed and calculated by statistical method.Results1.Through the single factor analysis and Logistic regression analysis of the basic related influencing factors of breast cancer patients and non-breast cancer population,it is concluded that lack of breastfeeding can be an independent risk factor of breast cancer.By comparing the premenopausal population and postmenopausal population,breast-feeding has a significant protective effect on the premenopausal population（P < 0.05）,but this protective effect is not significant in the postmenopausal population（P > 0.05）.2.By grouping and analyzing the age at which breast-feeding is started,it is found that breast-feeding under the age of 35 can significantly reduce the risk of breast cancer for women over the age of 35,among which breast-feeding at the age of30-34 has the most obvious protective effect（P < 0.05）.3.When we discuss whether breast-feeding has different protective effects on different breast cancer subtypes,we find that breast-feeding can significantly reduce the risk of hormone receptor-positive breast cancer compared with other subtypes through comparative analysis of patients with four different subtypes（P < 0.05）,but we have not found that breast-feeding has significant differences in the effects on Luminal A and Luminal B subtypes.4.When discussing whether there is a difference in the protective effect of different lengths of breast-feeding on breast cancer,we analyzed the duration of breast-feeding in groups and finally found that the protective effect of breast-feeding duration on breast cancer is nonlinear,and the duration of breast-feeding between 0and 6 months has the strongest protective effect on breast cancer.Conclusion1.Breastfeeding has obvious protective effect on breast cancer,and this protective effect can be obviously observed in premenopausal women,but it is not obvious for postmenopausal women,which needs further study.2.Compared with women who started breast-feeding after 35 years old,breastfeeding before 35 years old can obviously prevent breast cancer,and the protective effect was most significant when initiation of breastfeeding between 30 and34 years of age.3.The risk of hormone-positive breast cancer can be significantly improved by breast feeding,but the study has not observed that breast feeding has different effects on two different subtypes of Luminal A/B.4.The protective effect of breastfeeding was strongest between 0 and 6 months,followed by those over 12 months;The protective effect was slightly weaker at 7-12 months.