C-H Bonds Functionalization Of α-Amino Carbonyl Compounds

α-Amino-carbonyl is widely existed in a variety of natural products,drugs and functional materials materials,which is of great significance in the research of C-H functionalization.C-H bond functionalization has been considered as an attractive strategy to construct C-C bonds or C-X(X = N,O,P,S)bonds in recent years.Variousα-substituted α-aminocarbonyl compounds and complex structure molecules can be prepared through C-H bonds tansformation of α-amino carbonyl compounds.Herein,cross-dehydrogenative-coupling reactions of α-amino carbonyl compounds with various coupling partners by visible light or transition metal catalysis have been investigated.The main contents of the thesis are as follows:1.Visible-light-induced cross-dehydrogenative-coupling of α-amino carbonyl compounds with imidazole[1,2-a]pyridine was describled.Eosin Y was used as a photosensitizer,α-amino carbonyl compounds performed the cross-dehydrogenative-coupling reaction smoothly with imidazole [1,2-a] pyridine under air by visible light photocatalysis in ethanol.Various arylated α-amino carbonyl compounds were obtained in 20-85% yields.2.Copper-catalyzed cross-dehydrogenative-coupling reaction of α-amino ketone and benzimidazoles was developed.A series of N-substituted azoles were synthesized at room temperature by the catalysis of Cu Cl in acetonitrile under air,using benzoyl peroxide(BPO)as an oxidant.A large number of azoles involving benzimidazole,imidazole,pyrazole and triazole performed the coupling with α-amino ketones to afford the desired products.3.Visible-light-driven cross-dehydrogenative-coupling of α-amino carbonyl compounds with diphenylphosphine oxide.Bengal rose was used as a photosensitizer,oxygen as an oxidant,α-amino carbonyl compounds underwent the reaction with diphenylphosphine oxide in dimethyl sulfoxide(DMSO)by irradiation with 18 W blue LED at room temperature.A number of alkyl phosphate compounds were preparaed through C-P bond formation by the visible-light photocatalysis.