Controllable Synthesis Of Bimetallic Matrix Composites And Their Non-enzymatic Glucose Sensing Properties

Electrochemical non-enzymatic glucose sensor refers to an electrochemical glucose sensor that does not use enzyme as sensitive material.It can overcome some shortcomings of enzyme itself,such as the enzyme is easily influenced by temperature,humidity and pH value,which leads to the inactivation of enzyme and further affects the performance of the sensor.In many researches on sensitive materials of electrochemical non-enzymatic glucose sensors,precious metals have been used as electrode materials for electrochemical non-enzymatic glucose sensors for a long time,but the high price limits the large-scale commercial use of precious metals.Transition metals have been widely studied in the field of electrochemical non-enzymatic glucose sensing because of their low price,high electrochemical activity and good stability.In order to obtain a bimetallic electrochemical non-enzymatic glucose sensor with high sensitivity,low detection limit,excellent selectivity and low manufacturing cost,the following research contents have been done in this paper:（1）The flaky copper oxide composite silver nanoparticles（Ag/CuO）were synthesized by hydrothermal method.By changing the ratios of Cu to Ag in the reactants,the size and morphology of the composite materials were accurately controlled.Flake morphology is beneficial to the full adsorption and desorption between sensitive materials and glucose,and increases the chance of glucose contacting with the active sites of sensitive materials.The electrochemical performance of the working electrode based on the bimetal matrix composite was studied.The results showed that the electrode modified by Ag/CuO composite material had outstanding sensing performance for glucose with a sensitivity of 1681.21μA·m M^-1·cm^-2 under the applied voltage of+0.60 V.The glucose content of actual saliva samples was detected,which proved its application potential in the field of non-invasive and non-enzymatic glucose sensing.（2）One-dimensional CuO-SnO_x composites modified by amorphous tin oxide were prepared by hydrothermal method and sintering method.The sensitivity of the sensor is 2303μA·m M^-1·cm^-2,and the detection range is 1μM to 6000μM m.The sensor has good selectivity for interfering substances such as dopamine,lactic acid,ascorbic acid and sodium chloride.TPO confirmed that the amorphous tin oxide modified copper oxide nanorod composites had oxygen vacancy defects,which greatly improved the electrochemical performance of the sensor.Therefore,the sensor has good electrochemical performance and can be used to detect practical saliva samples with low glucose content.The sensor constructed by CuO-SnO_x complex can detect the changes of glucose content in saliva of volunteers before and after meals.The glucose content in saliva measured by electrochemical method is closely related to the blood glucose level measured by a commercial blood glucose meter.Structure-induced oxygen-enriched vacancy defects can improve the performance of the sensor,which may provide some new ideas for the synthesis of high-performance sensor composites.