Optical Changes In Dysfunctional Lens Syndrome Measured With Different Instruments

Purpose:To evaluate the visual quality,particularly,higher-order aberrations of the Dysfunctional Lens Syndrome(DLS)eyes,by using different diagnostic ophthalmic instruments and the Visual Function Index-14(VF-14)questionnaire.Methods:25 patients(40 eyes),15 eyes(10 subjects)corresponding to a group of normal subjects;and the other 25 eyes(15 patients)who have results consistent with dysfunctional lens syndrome,and with BCVA>0.5 and natural pupil diameter≥4mm were included.Among them 14 females(23 eyes)and 11 males(17 eyes).Higher-order aberrations were measured by using OPD-Scan III and iTrace and OQAS HD-analyzer was also carried out for measuring the OSI level.Additionally VF-14 questionnaire was also conducted.Results:Both the OPD-scan III and iTrace have shown significant difference of total internal HOAs between the experimental and control groups(P<0.05).In contrast,there was no statistical difference in corneal higher-order aberration levels between the two groups(P>0.05).The final v-14 questionnaire score of the experimental group(60.72±21.90)was lower than the score of control group(77.39±13.57)(P<0.05).Conclusion:The experimental subjects were only able to do limited activities despite having a relatively good BCVA(0.74±0.22)and low OSI value(1.26±0.57).Based on that,it highlights that the crystalline lens is possible source of these patient’s discomfort in the absence of cataract.Higher-order aberration of DLS is mostly due to internal ocular aberrations;therefore applying this in the clinical or surgical management can be helpful.