Correlation Of Hs-CRP,Homocysteine And Progressive Ischemic Stroke

Objective: High-sensitivity C-reactive Protein(hs-CRP)is mainly a biomarker of inflammation and a sensit ive predictor of stroke,and Homocysteine(Hcy)is also associated with stroke.In this paper,patients with progressive ischemic stroke(progres sive ischemic stroke,PIS)were studied to explore whether the occurrence of progressive ischemic stroke is related to factors such as hs-CRP and homocysteine,analyze the correlation with progressive strok e,and provide theoretical basis for the prevention of progressive ischemic stroke and the occurrence of progressive stroke.Methods: The clinical data of patien ts with acute ischemic stroke(Acute ischemic stroke,AIS),who went to the Department of Neuro logy of the Affiliated Hospital of Yanbi an University from November 2020 to October 2021,were selected for retrospectively analysis,and 182 patients were selected by inclusion and exclusion criteria.According to the patient onset within 6 hours to 7 day s,whether the neurological defect sympto ms of progressive aggravation,and to evaluate the National Institutes of Health stroke scale(National Institutes of He alth Stroke Scale,NIHSS)score increased by 2 points compared with admission,divided into progressive ischemic stroke(PIS)group and non-progressive ischemic stroke(nonprogressive ischemic stroke,NPIS)group.General clinical data(age,gender,ethnicity,smoking history,alcohol consumption history,previous history,etc.)were collected,and statistical analysis was conducted between the two groups was conducted according to hypersensitive c-reactive protein and homocysteine.Multivariate Logistic regression was used to analyze the factors affecting PIS in acute ischemic stroke patients,and t he correlation of high-sensitivity c-reactive protein,homocysteine and PIS was evaluated using subjects(receiver operating characteristic curve,ROC).Result:1.The rate of progressive stroke was higher than those with no previous history of hypertension,and no significant difference in age,gender,ethnicity,diabetes,smoking history,alcohol history and admission NIHSS score,P> 0.05.2.Patients with hs-CRP had higher rates of progressive stroke in hs-CRP> 3mg/L and Hcy> 15 u mol/L than those with h s-CRP 3 mg/L and HCY 1 5 u mol/L,respectively,with significant differences(h s-C R P and Hcy than those with complete stroke,with significant differences,P <0.05).3.ROC curves for the predictive value of Hcy,hs-CRP,hypertension and progressive stroke,respectively,showed AUC of 0.590,0.677,0.617 and 0.755,respectively,where the value of the combined test was significantly higher than the individual index P <0.05.Conclusion:1.The occurrence of progressive stroke may be associated with hypertension,homocysteine(Hcy),and high-sensitivity C-reactive protein(Hs-CRP).2.Hypertension,homocysteine(Hcy),and high-sensitivity C-reactive protein(Hs-CRP)are all independent risk factors for progressive stroke.3.Combined detection of multiple i ndicators can improve the diagnostic value of progressive s troke,among which hypertension,homocysteine(Hcy)and high-sensitivity C-reactive protein(Hs-CRP)jointly test the best diagnosis and predict the incidence of progressive stroke.