| Objective:Based on the literature research,clinical research and Delphi method to select the stable angina pectoris of coronary heart disease,improve the ability of syndrome differentiation and treatment,digital research demonstration syndrome,in order to promote the research of standardization and quantification of TCM syndrome,and to realize the Digital Research of TCM syndrome,so as to enhance the ability of TCM syndrome differentiation and treatment.Methods:1.By means of literature survey and frequency statistics,the distribution of TCM syndromes and syndrome elements of coronary heart disease(CHD)stable angina pectoris was analyzed.2.Using cross-sectional survey,based on frequency statistics and cluster analysis,the distribution of clinical information of stable angina pectoris was analyzed.3.Using the Delphi Method,an expert questionnaire was designed based on the results of literature surveys and cross sectional studies,the 18 experts were given a questionnaire about the demonstrative syndrome of coronary heart disease stable angina pectoris.In view of the four diagnostic information’s clinical universality,clinical specificity,machine recognition and the clinical common degree of syndrome type,we evaluate it strongly,strongly,moderately,weakly and weakly.A total of two rounds of expert questionnaire survey were conducted,each round of the questionnaire was analyzed according to the degree of concentration and coordination of expert opinions according to the mean,grade sum and coefficient of variation,preliminary determination of coronary heart disease stable angina pectoris Chinese medicine differentiation of symptoms and signs to enhance the ability of digital research demonstration.Results:1.Literature ResearchA total of 954 articles were included,including 967 records of syndrome types,covering 77,298 patients.The study found that the syndromes with the frequency of literature over 5% of stable angina pectoris are Qi deficiency and blood stasis syndrome,phlegm turbid and blood stasis syndrome,heart blood stasis syndrome,Qi stagnation and blood stasis syndrome,Qi deficiency and phlegm stasis syndrome,and phlegm blocking heart vessels syndrome,the frequency of syndrome was 74.5%.The disease location is mainly in the heart,followed by the kidney,spleen,liver;the deficiency of venereal diseases is mainly qi deficiency,followed by Yin deficiency and Yang deficiency;The combination of two syndrome elements is the most common form of syndrome combination,and the distribution of true and false syndrome is the same as that of pure positivism.2.Clinical researchThe most frequent symptoms of 478 patients were chest tightness,chest pain and palpitation,followed by pulse astringency,tongue purple,tongue dark,shortness of breath,tongue ecchymosis and petechia.80 items of four diagnostic information with a frequency greater than 2% were grouped into 7categories with clinical significance.After differentiation of symptoms and signs by experts,the first category was presumed to be phlegm-turbidity syndrome,the second category was presumed to be blood-stasis syndrome,and the third category was the common symptom of each syndrome,the fourth type is the supposition of Qi stagnation syndrome,the fifth type is the cold syndrome,the sixth type is the Yin deficiency syndrome,and the seventh type is the Qi deficiency syndrome.3.Delphi methodThe positive coefficients of experts in two rounds of questionnaire investigation were 100% and 83.33% respectively.The demonstrative syndrome of Digital Research was blood stasis syndrome,Qi deficiency syndrome and phlegm turbidity syndrome.The specific four diagnostic information of blood stasis syndrome are: tingling,pain is fixed,pain is aggravated at night,complexion is purple dark,lips are purple dark,tongue is dark,tongue has petechiae,sublingual veins are tortuous and blue,pulse is astringent;The specific four diagnostic information of Qi deficiency syndrome are: pain and fatigue,mental fatigue,tiredness,fatigue,shortness of breath,lazy speech,spontaneous sweating,pulse sinking;The specific four diagnostic information of phlegm-turbid syndrome are: the pain is easy to attack or aggravate in rainy days,the head is heavy,the body is fat,the limbs are heavy,the stool is greasy,the tongue is fat,the tongue has teeth marks,the mouth is sticky,the fur is greasy,the fur is thick,the fur is slippery,the pulse is slippery,pulse string.Conclusion:The demonstrative syndrome of Digital Research was blood stasis syndrome,Qi deficiency syndrome and phlegm turbidity syndrome.The specific four diagnostic information of blood stasis syndrome are: tingling,pain is fixed,pain is aggravated at night,complexion is purple dark,lips are purple dark,tongue is dark,tongue has petechiae,sublingual veins are tortuous and blue,pulse is astringent;The specific four diagnostic information of Qi deficiency syndrome are: pain and fatigue,mental fatigue,tiredness,fatigue,shortness of breath,lazy speech,spontaneous sweating,pulse sinking;The specific four diagnostic information of phlegm-turbid syndrome are: the pain is easy to attack or aggravate in rainy days,the head is heavy,the body is fat,the limbs are heavy,the stool is greasy,the tongue is fat,the tongue has teeth marks,the mouth is sticky,the fur is greasy,the fur is thick,the fur is slippery,the pulse is slippery,pulse string. |