| Objective: To objectively evaluate the clinical efficacy and safety of tonifying the kidney and regulating the middle of the body soup in the treatment of chronic renal failure with gastrointestinal symptoms,and to provide a basis for clinical promotion and application.Methods:Sixty-six cases meeting the inclusion criteria were randomly divided into test group and control group,33 cases in each group.Both groups were treated with conventional Western medicine for patients with chronic renal failure,and the control group was given conventional treatment plus pantoprazole enteric tablets for gastrointestinal symptoms,while the test group was given conventional treatment plus oral administration of tonifying kidney and toning Chinese soup,and the duration of treatment for both groups was 8 weeks.The differences in renal function(Scr,BUN,GFR),gastrointestinal symptom grading score,nutritional status(ALb,TP,Hb),gastrin 17(GAS-17),TCM syndrome score and safety indexes between the two groups before and after treatment were observed and statistically analyzed.Results:(1)Comprehensive clinical efficacy: the total effective rate of the test group was 93.6%,and the total effective rate of the control group was 75.0%,and the efficacy of the test group was better than that of the control group(P < 0.05);(2)Renal function: the Scr and BUN levels decreased significantly in both groups after the test(P < 0.01),and the e GFR level increased significantly in both groups(P < 0.01);and the test group was better than the control group in reducing the Scr and BUN levels and improving the GFR(P<0.05).(P < 0.05);(3)Gastrointestinal symptom grading score: the gastrointestinal tract score decreased significantly in both groups after the test(P < 0.01),and the efficacy of the test group was better than that of the control group(P < 0.05);(4)Nutritional indexes: the levels of ALb,TP and Hb improved significantly in both groups after the test(P < 0.01),and the efficacy of the test group in improving TP and Hb was significantly better than that of the control group(P < 0.01).(P < 0.01)and for improving ALb levels(P < 0.05)in the control group;(5)gastrointestinal hormones: the GAS-17 levels in both groups were significantly lower after the test compared with those before treatment(P < 0.01),and the degree of reduction in the test group was better than that in the control group(P <0.05);(6)comparison of the efficacy of the Chinese medicine symptoms: the total effective rate in the test group was The efficacy of the test group was better than that of the control group(P < 0.05);(7)safety indexes: no abnormal changes in blood routine,urine routine,stool routine + occult blood,liver function and electrocardiogram were observed before and after the test in both groups.Conclusion: The clinical application of tonifying the kidney and harmonizing the middle of the body soup in the treatment of chronic renal failure can alleviate gastrointestinal symptoms and delay renal decompensation,with definite efficacy and better safety. |
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