| Objective: This article grasps the overall pathogenesis of blood and Qi disharmony or Qi and blood loss in POAG,and adopts the comprehensive therapy of foot bath with traditional Chinese medicine,bloodletting at ear point and pressing beans at ear point.By verifying the effectiveness and safety of this TCM Comprehensive therapy,it provides a new clinical scheme for the treatment of POAG,and shares a new idea to improve the standardization of TCM clinical randomized controlled trials with the majority of doctors.Methods: According to the inclusion criteria of this trial,46 cases(86eyes)were included and randomly divided into 23 cases(43 eyes)in the control group and 23 cases(43 eyes)in the test group.Both groups were treated with brinzolamide eye drops and sijilin capsules.On the basis of Western medicine treatment,the experimental group was treated with auricular point bleeding,auricular point bean pressing and traditional Chinese medicine foot bath.The patients in the experimental group were treated with traditional Chinese medicine comprehensive therapy for 10 days,a course of treatment,a total of 5 courses,and the auricular point was bled every two days.The interval between each course of treatment was 2 days.During the interval,the patients were examined for blood routine examination and eight items of infection.During this period,the patients in both groups took sizilin capsule for 60 days,and the patients in both groups used brinzolamide eye drops for 30 days from the first day of the trial.The visual acuity,visual field,RNFL and other indicators were rechecked after all treatment.The data of the two groups before and after treatment were compared,and the safety of the patients was evaluated.Result:(1)The visual acuity of the patients in the test group before and after treatment was compared within the group.T-test analysis showed that the p value was 0.001 < 0.01,and the difference was statistically significant.After treatment,compared with the control group,the visual acuity of the test group was 0.009 < 0.01,the difference was statistically significant.The effective rate of visual acuity improvement in the experimental group was83%,and that in the control group was 41%.The effective rate in the experimental group was significantly better than that in the control group.(2)The intraocular pressure of the test group and the control group before and after treatment were compared within the group,P values were less than0.01,there were significant statistical differences.The intraocular pressure of the experimental group and the control group after treatment was compared between the two groups(P < 0.01),which also had significant statistical difference.The mean intraocular pressure in the test group was about 16 mmhg,and that in the control group was about 19 mmhg.The treatment effect of the test group was better than that of the control group.(3)Among the 40 people who completed the trial,1 person developed transient dizziness and improved after 1 day of rest;One person’s intraocular pressure fluctuated briefly and improved after two days of treatment.Both completed the experiment.The safety rate of this test is 95%,and the general safety rate is 100%.(4)There was no significant difference in other indicators.All data before the test are comparable.Conclusion: This clinical trial has proved that the comprehensive therapy of traditional Chinese medicine has little effect on the main efficacy index visual field,but it can prevent its further deterioration.It has a very good effect on intraocular pressure and visual acuity,and it also has the possibility to promote the recovery of the optic nerve.It is very safe and reliable,with little drug resistance.It can better protect the visual function of patients with western medicine.This clinical trial also provides a new idea for the standardization of clinical randomized controlled trials of traditional Chinese medicine. |
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