| Objective:To explore the changes of syndrome type and blood pressure in people with hyperactive liver fire with prehypertension,and to compare the changes of biochemical indexes and the correlation of related risk factors among different syndrome types,so as to provide theoretical basis for the differentiation of syndromes of prehypertension and the early prevention of hypertension.Methods:A total of 200 subjects with prehypertension and hyperactivity syndrome of liver fire were collected from January 2019 to June 2020 in the Department of Heart Disease,Affiliated Hospital of Shandong University of Traditional Chinese Medicine.They were followed up 18 months after the first observation(i.e.,July 2020 to December 2021),and the data obtained were statistically analyzed.Results:1.Among the 200 subjects with prehypertension and hyperactive syndrome of liver fire,15.5% turned to excessive phlegm-dampness syndrome,20% to Yin deficiency and Yang hyperactivity syndrome,and 7.5% to deficiency of both Yin and Yang during the 18-month return visit.There were statistically significant differences in fasting blood glucose,serum uric acid,creatinine,glomerular filtration rate,blood homocysteine,thyroid stimulating hormone,anterior and posterior diameter of left atrial,anterior and posterior diameter of left ventricle in hyperhepatosis group compared with before observation(P < 0.05).There were statistically significant differences in fasting blood glucose and serum uric acid of excessive phlegm-dampness syndrome compared with before observation(P<0.05).2.Among the 200 subjects with prehypertension and hyperactivity syndrome of liver fire,13% had normal blood pressure and 6% developed hypertension at 18 months follow-up.There were statistically significant differences in serum uric acid,creatinine,glomerular filtration rate,blood homocysteine and anterior and posterior diameter of left atrial in prehypertension group compared with before observation(P<0.05),and statistically significant differences in triglyceride(TG)in hypertension group compared with before observation(P<0.05).3.There were significant differences in BMI,triglyceride,HDL-C and serum uric acid among different syndrome types(P<0.05).There were statistically significant differences in BMI between the syndrome of excessive phlegm-dampness and the syndrome of excessive liver fire,Yin deficiency and Yang deficiency,and the syndrome of deficiency of both Yin and Yang(P<0.01),statistically significant differences in triglyceride and HDL-C between the syndrome of excessive liver fire and the syndrome of excessive phlegm-dampness(P < 0.01),and statistically significant differences in serum uric acid between the syndrome of excessive phlegmdampness and the syndrome of Yin deficiency and Yang deficiency(P<0.01).4.BMI,LDL-C,TC,ventricular septum and left ventricular ejection fraction(EF)were significantly different among different blood pressures(P<0.05),and there were statistically significant differences between normal blood pressure and prehypertension(P < 0.05).There were statistically significant differences in blood pressure combined with cerebral infarction,diabetes,carotid atherosclerosis or carotid plaque formation among the three groups(P<0.05),and there were statistically significant differences in blood pressure combined with cerebral infarction,carotid atherosclerosis or carotid plaque formation between normal blood pressure and prehypertension(P < 0.025).There were statistically significant differences between normal blood pressure and hypertension combined with diabetes,carotid atherosclerosis or carotid plaque formation(P<0.025).5.Multivariate logistic regression analysis showed that compared with the syndrome of excessive phlegm-dampness,people with high LDL-C and BMI tended to have excessive phlegm-dampness syndrome.Compared with Yin deficiency Yang hyperactivity syndrome,people with high fasting blood glucose tend to have Yin deficiency Yang hyperactivity syndrome.Compared with the syndrome of Yin deficiency and Yang hyperactivity,people with high BMI tended to have the syndrome of excessive phlegm-dampness.Compared with the deficiency of Yin and Yang,people with high LDL-C tend to have excessive accumulation of phlegm and dampness.Conclusion:Observe the changes of syndrome type in 200 subjects with prehypertension hyperactive syndrome of irascibility,part of the patients with hyperactive syndrome of irascibility changed before and after,and blood pressure changed.There were differences in BMI,HDL-C,triglyceride and serum uric acid among different types(P < 0.05).There was statistically significant difference in triglyceride from prehypertension to hypertension(P < 0.05).There were differences in BMI,LDL-C,triglyceride,ventricular septum and EF among the three groups(P<0.05).There were differences among three groups in blood pressure complicated with cerebral infarction,diabetes mellitus,carotid atherosclerosis or carotid plaque formation(P<0.05).Compared with the syndrome of excessive accumulation of phlegm and dampness,people with high BMI had more abundant accumulation of phlegm and dampness.Compared with the syndrome of excessive liver-fire and deficiency of Yin and Yang,people with high LDLC had more abundant phlegm-dampness.Compared with the syndrome of Yin deficiency and Yang hyperactivity,the syndrome of Yin deficiency and Yang hyperactivity in people with high fasting blood glucose was more. |
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