Clinical Observation Of Acupoint Catgutembedding Therapy In The Treatment Of Premature Ovarian Dysfunction

Objective:This paper selects patients with kidney deficiency type premature ovarian insufficiency（POI）as the research object.And investigate the general information,sex hormone levels,tumor necrosis factor（TNF-a）,and mental,psychological,and sleep quality of such patients to summarize the influencing factors of POI.At the same time,using acupoint catgut embedding as an intervention method,comparing the effect of acupoint catgut embedding combined with estrogen and progesterone therapy and estrogen-only progesterone therapy on POI patients,which provided new ideas for the clinical treatment of POI.Methods:The study was conducted in the outpatient department of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from September 2020 to December 2021.There were 60 patients who met the diagnosis and inclusion criteria in this study.The control group was treated with oral Fencode,and the treatment group was treated with oral Fencode and catgut embedding stimulation.The TNF-a,sex hormones and other indicators of patient were detected,and a questionnaire survey was conducted on the general personal information,stress,sleep quality,and mental health status of patient.After 3 cycles of treatment,the two groups of patients were tested for relevant indicators again and filled out questionnaires.The above data were collected after the treatment,and processed and analyzed with Excel software.IBM SPSS 26.0 software was used to explore the correlation and significance between the data results（P<0.05 indicates a significant difference）Results:1.Among the 60 POI patients,28 patients（46.67%）had follicle-stimulating hormone（FSH）>25,and 32 patients（53.33%）had 15<FSH<25（subclinical POI）.In the correlation analysis,the anxiety and depression scores were positively correlated with the total score of TCM syndromes（P<0.05）,the sleep quality score was negatively correlated with the estradiol（E₂）value,and the TNF-a was positively correlated with FSH（P<0.05）.2.Both groups could effectively improve menstrual conditions after treatment,soreness and weakness of waist and knees,insomnia,dreaminess,loss of libido and other symptoms,and the difference was statistically significant（P<0.05）.The treatment group was better than the control group in improving menstruation and kidney deficiency symptoms,and the difference was statistically significant（P<0.05）.3.The levels of FSH,E2,luteinizing hormone（LH）and antral folli cle count（AFC）in the two groups were improved compared with those before treatment（P<0.05）after treatment.The curative effect of AFC and FSH in the treatment group was better than that in the control group（P<0.05）.There was no significant improvement in the values of TNF-a and anti-mullerian hormone（AMH）before and after treatment in the two groups（P<0.05）,which was not statistically significant.4.The treatment group had curative effect in improving depression,anxiety and sleep quality（P<0.05）.There was significant difference between the two groups,and the treatment group had better curative effect（P<0.05）.Both the treatment group and the control group had reliable curative effects,and the total effective rates were 86.66%and 66.66%,respectively.The curative effect of the treatment group was better（P<0.05）.Two patients in the treatment group developed local redness and swelling during the treatment period,which did not affect the later treatment.One case in the control group developed palpitation and nausea,which was relieved after rest and did not affect the follow-up treatment.Conclusion:1.Anxiety,depression,and sleep quality are all correlated with the occurrence of POI,and social and psychological factors largely affect the clinical symptoms of POI patients.2.The efficacy of POI patients in TCM syndrome,hormone indicators,anxiety,depression,sleep quality scores and other aspects are better than those of the simple oral Fenmatong group after acupoint catgut embedding intervention.Although both acupoint catgut embedding and oral administration of Fenmatong have safety risks,acupoint catgut embedding treatment is relatively safe and reliable,and is worthy of clinical promotion.