Study On The Correlation Between Cerebral Microhemorrhage,Cognitive Impairment And Constitution Of Traditional Chinese Medicine

Objective: To explore the relationship between cerebral microbleeds(CMBs)and cognitive impairment(MCI),observe and classify Analysis of the distribution characteristics of patients with cerebral microbleeds in various TCM constitutions,for the early clinical prevention and treatment of TCM It provides an important guiding basis for the treatment of cognitive impairment in cerebral microbleeds.Method: Select December 1,2020 CMBs visiting the Neurology Department of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 1,2022 120 CMBs patients were selected as the observation group.According to the examination results of MRI-SWI,refer to Gregoire et al.The MARS assessment scale was developed,and the CMBs were graded according to the number of CMBs in each anatomy.There were 39 people in the mild group,46 people in the moderate group,and 35 people in the severe group.90 cases of normal people with head MRI confirmed by physical examination in the Second Affiliated Hospital of Medical University Subjects were tested for overall cognitive abilities,along with memory(immediate memory,long-term memory,extended memory)independent examination of 4 cognitive domains,executive/attention,language,and visuospatial,analysis The relationship between senile cerebral microhemorrhage and cognitive dysfunction,while improving blood pressure,blood sugar and blood lipids All research subjects completed the "Traditional Chinese Medicine Constitution Determination Table" according to the physical The 9 subscales of the classification of constitution were used to study the distribution and characteristics of TCM constitution in patients with CMBS.Results: 1.Compared with the control group: 1)In the mild group,the overall cognitive ability(Mo CA assessment),long-term The difference in memory(HVLT assessment)was statistically significant;2)The moderate group had a higher overall cognitive ability(Mo CA assessment),immediate memory,long-term memory,delayed recognition(HVLT assessment),executive function(TMT-B assessment),the differences in visuospatial ability(CDT assessment)scores were all statistically significant;3)In the severe group,overall cognitive ability(Mo CA assessment),attention and processing speed(TMT-A assessment) assessment),executive function(assessed by TMT-B),language function(assessed by BNT-2),immediate memory,long-term memory There were uniform differences in long-term memory,delayed recognition(HVLT assessment),and visuospatial abilities(CDT assessment).Accounting meaning.2.Compared with the mild group:1)the moderate group had better performance in long-term memory,delayed recognition,attention and processing speed,The differences in language function scores were not statistically significant,and the differences in other test scores were statistically significant 2)In the severe group,the overall cognitive ability,attention and processing speed,executive function,language Functional,immediate memory,long-term memory,delayed recognition,and visuospatial abilities were statistically different righteous.3.Compared with the moderate group,the severe group showed improvement in overall cognitive ability,attention and processing speed,executive function,Language function,immediate memory,long-term memory,delayed recognition,and differences in visuospatial abilities are all consistent.Accounting meaning.4.There are statistical differences between the control group and the observation group in the distribution of peaceful,biased and biased constitutions.Among them,the biased constitutions of the observation group were mainly composed of blood stasis,yang deficiency,phlegm dampness and qi deficiency.5.There was no significant difference in the distribution of biased constitution between the moderate group and the severe group;compared with the mild group,There was a statistical difference in the distribution of biased constitution between the moderate group and the severe group.Blood stasis and phlegm-dampness were the main types,while in the mild group,Qi-deficiency and yang-deficiency were the main types.Conclusions: 1.CMBs patients have cognitive impairment in multiple areas,and the mild group patients mainly show overall cognitive impairment.Cognitive ability,long-term memory impairment,attention,executive ability,language and visual space impairment are not obvious;The patients in the moderate group mainly showed overall cognitive ability,immediate memory,long-term memory,delayed recognition,visual Spatial ability,impairment of executive function,and language impairment are not obvious;severe group may have extensive cognitive impairment.damage to the domain.2.CMBs patients have a common constitution bias,among which blood stasis,phlegm-dampness,yang-deficiency and qi-deficiency are the most common.Mainly,the patients in the severe group and the moderate group were mainly characterized by blood stasis and phlegm-dampness,and the mild group were mainly characterized by qi deficiency and yang deficiency.main.