Study On The Risk Factors Of Liver Fibrosis In Metabolic-related Fatty Liver Disease In Zunyi City

Objective: By understanding the risk factors associated with liver fibrosis through metabolic associated fatty liver disease(MAFLD),for early intervention,reduce and reverse the development of liver fibrosisin,order to further reduce the risk of development and death of liver-related diseases in MAFLD patients.Methods: The medical examination population who met the inclusion and exclusion criteria within 6 months of the Physical Examination Department of the Affiliated Hospital of Zunyi Medical University were selected and included in this study in turn for investigation.According to the results of i Liv Touch examination,they were divided into group A,that is,the group with only MAFLD(median fat attenuation≥240db/m,N=131 cases),and group B,that is,the group of MAFLD combined with liver fibrosis(median fat attenuation ≥240db/m and median liver stiffness ≥7.3KPA,N=157 cases).Collect the basic information of the research subjects,knowledge of fatty liver,sleep status,smoking history,drinking history,sedentary habits,etc.All selected subjects recorded body mass index(BMI),blood pressure,waist circumference and hip circumference,and fasting blood glucose,2-hour postprandial blood glucose,insulin determination,glycated hemoglobin,blood lipids(triglycerides,total cholesterol,high-density lipoprotein cholesterol,low-density lipoprotein cholestero),renal function(Urea,Creatinine),uric acid,liver function(alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyltransferase(GGT),alkaline phosphatase(ALP)),albumin,total bilirubin),hypersensitive C-reactive protein.Enter the data collected above into the database as required,statistical analysis was performed using SPSS 23.0 software.Measurement data are expressed as ±s.The comparison between the two groups was performed using an independent sample t test,the count data are expressed by frequency and composition ratio,comparisons between groups were performed using the chi-square test.The risk factors were analyzed by binary logistic regression analysis.P<0.05 was considered statistically significant.Results: There were 288 MAFLD patients who met the inclusion and exclusion criteria.Univariate analysis indicated that age,working or not,marital status,BMI,waist circumference,hip circumference,systolic blood pressure,knowledge of fatty liver,alanine aminotransferase,aspartate aminotransferase,alkaline The levels of phosphatase,insulin,high-sensitivity C-reverse protein and the occurrence of liver fibrosis were statistically significant(P<0.05).Gender,ethnicity,education level,family annual income,smoking history,drinking history,diastolic blood pressure,average daily sedentary time,average daily sleep time,previous liver diseases,dyslipidemia,hypertension,coronary heart disease,lung Diseases,stroke,type 2diabetes,gout/hyperuricemia,osteoporosis,rheumatoid arthritis and other diseases,blood lipids,total protein,albumin,total bilirubin,glycosylated hemoglobin,blood sugar,renal function,There was no statistical difference between uric acid and the occurrence of liver fibrosis(P>0.05).The results of multivariate Logistic regression model analysis showed that age,BMI,and aspartate aminotransferase(AST)had significant effects on liver fibrosis in MAFLD patients(P<0.05).Conclusion: The results of this study showed that by controlling BMI(such as a balanced diet,proper exercise,etc.)and avoiding liver function damage,AST can be controlled within the normal range(not taking liver-damaging drugs,abstaining from alcohol,etc.),avoid related risk factors,may play a role in reducing the risk of liver fibrosis,liver-related diseases and death in patients with MAFLD in Zunyi City.