Study On The Correlation Between Spleen-stomach Damp-heat Syndrome,spleen-stomach Qi Deficiency Syndrome And Intestinal Bacterial Overgrowth In Hp Related Chronic Gastritis

Objective:In order to detect SIBO,lactulose hydrogen breath test was performed in patients with Helicobacter pylori associated chronic gastritis of spleen-stomach damp-heat syndrome or spleen-stomach qi deficiency syndrome.So as to explore the correlation between TCM syndrome types of Helicobacter pylori associated chronic gastritis and SIBO.Objective to provide relevant basis for the treatment of Helicobacter pylori associated chronic gastritis and TCM clinical syndrome differentiation.Methods:Sources of cases: From February 2021 to February 2022,there were 100 patients who met the diagnostic criteria and inclusion criteria of this study in health management center,outpatient and inpatient department of our hospital.The relevant information of patients was recorded: general basic data,abdominal clinical symptoms(asymptomatic,abdominal pain,diarrhea,abdominal distension,complications),four diagnosis data,gastroscopy diagnosis,pathological results(HP,chronic inflammation,activity,atrophy,intestinal metaplasia),13C-UBT,LHBT results and other data.Furthermore,the syndrome differentiation of TCM was performed,for which the related database was established,to get the relevant research results of Helicobacter pylori associated chronic gastritis with spleen-stomach damp-heat,spleen-stomach qi deficiency and SIBO by statistical analysis.Results:1.General data:(1)Among 100 patients with Helicobacter pylori associated chronic gastritis,the incidence group was mainly young and middle-aged.(2)In terms of TCM syndrome types,there was no difference in age and gender between Spleen-stomach Damp-heat and Spleen-stomach qi deficiency(P>0.05).2.TCM syndrome type and DOB value: There was difference in DOB value between the two groups(P<0.05).In the DOB value>35,the number of patients in Spleen-stomach Damp-heat was significantly higher than that in Spleen-stomach qi deficiency.3.TCM Syndrome Types and gastroscopic manifestations: There were differences in mucosal congestion and erosion between the two groups(P<0.05).Spleen-stomach Damp-heat was mainly local and multi site congestion and erosion,and Spleen-stomach qi deficiency was mainly non and local site congestion and erosion.4.TCM Syndrome Types and gastric mucosal pathology: There were differences in mucosal activity between the two groups(P<0.05).Spleen-stomach Damp-heat was mainly moderate and severe,and Spleen-stomach qi deficiency was mainly mild and moderate.5.SIBO and age and sex: There was no difference in age and sex between SIBO positive group and SIBO negative group(P>0.05).6.SIBO and abdominal clinical symptoms: There was no difference in clinical symptoms such as asymptomatic,abdominal pain,diarrhea,abdominal distension and complications between SIBO positive group and SIBO negative group.7.SIBO and gastroscopic atrophy: There was a difference in the diagnosis of endoscopic atrophy between SIBO positive group and SIBO negative group(P<0.05).The positive rate was positively correlated with the diagnosis of endoscopic atrophy.8.SIBO and gastric mucosal pathology: There were differences in mucosal activity and atrophy between SIBO positive group and SIBO negative group(P<0.05),and the positive rate was positively correlated with mucosal activity and atrophy.9.TCM Syndrome Types and SIBO: There was a difference in the positive rate of SIBO between the two groups(P<0.05).The positive rate of SIBO in Spleen-stomach Damp-heat was higher than that in Spleen-stomach qi deficiency.10.SIBO and OCTT: There was no difference in OCTT between SIBO positive group and SIBO negative group(P>0.05).Conclusions:1.Helicobacter pylori associated chronic gastritis with Spleen-stomach Damp-heat is correlated with higher DOB value,scope of mucosal congestion and erosion under gastroscope and severity of pathological activity of mucosal,and higher than Spleen-stomach qi deficiency.2.With the aggravation of gastric mucosal activity and atrophy,the incidence of Helicobacter pylori associated chronic gastritis with SIBO positive also increased.3.In Helicobacter pylori associated chronic gastritis,the positive rate of SIBO in chronic atrophic gastritis is higher than that in chronic non-atrophic gastritis.Also,the positive rate of SIBO in Spleen-stomach Damp-heat is higher than that in Spleen-stomach qi deficiency.