| Purposes:The aim of this study is to explore the therapeutic effect of Jiawei Taohong Wuling Powder on the bl ood stasis and water cessation of macular edema after diabetic cataract surgery based on the treatment methods of promoting blood circulation and removing blood stasis,strengthening the spleen and diverting water.Method:A total of 70 patients(70 eyes)with blood stasis and water stasis syndrome of macular edema after diabetic cataract surgery who met the inclusion criteria were selected as the research objects,and they were randomly divided into a treatment group(35 cases,35 eyes)and a control group(35 cases,35 eyes),the control group was given conventional PCME prevention and treatment drugs(tobramycin and dexamethasone eye drops,bromfenac sodium eye drops),and the treatment group was given oral treatment with modified Taohong Wuling powder on the basis of the control group.taking 2 weeks as a treatment cycle,3 consecutive treatment cycles,follow-up for 3 months after treatment,record the central macular thickness(CMT)of the macular center area of the fundus before and after treatment,the best corrected visual acuity(BCVA),the change of systemic syndromes,and observe the occurrence and recurrence of complications.Result:1.Generally speaking,in terms of age,gender,course of diabetes and the proportion of diabetic retinopathy in the treatment group and the control group,statistical analysis shows that there is no significant difference between the two groups of data.Gender comparison(c2= 0.230,P>0.05),age comparison(t=-0.31,P>0.05),and course comparison(t=-0.56,P>0.05)are comparable.2.In terms of BCVA,the BCVA baseline of the pre-medication treatment group was 0.23±0.16(`x±s),and the BCVA baseline of the control group was 0.24±0.14(`x±s).After statistical analysis,there was no significant difference between the two groups of data(t=-0.33,P>0.05),which was comparable;After one treatment cycle of medication,the BCVA of the two groups was improved compared with that before medication.After statistical analysis,the data showed significant differences and statistical significance(t treatment group=22.85,t control group=2.67,both P<0.05).Compared between the groups,the data of the two groups had no statistical significance(t=1.27,P>0.05);After 2 treatment cycles,the BCVA of the two groups continued to increase.There was statistical significance in the comparison between the treatment group and the control group in the 1st and 2nd cycles(t treatment group=8.382,t control group=3.697,both P<0.05),and there was no statistical significance in the comparison between the two groups(t=1.89,P>0.05);After 3 treatment cycles,the BCVA of the two groups of patients increased.Compared with the 2nd and 3rd cycle groups of the two groups,there was no statistical significance after statistical analysis(t treatment group=1.93,t control group=1.02,both P>0.05).Compared with the third treatment cycle group,after statistical analysis,the data had statistical significance(t=3.84,P<0.05);3.In terms of CMT,the CMT baseline of the pre-medication treatment group is 381.21±52.78μm(`x ±s),and the CMT baseline of the control group is 392.90±55.68μm(`x ±s).After statistical analysis,there is no significant difference between the two groups of data(t=-0.90,P>0.05),which is comparable;After one treatment cycle of medication,the CMT of the two groups decreased significantly.Compared with before medication,statistical analysis showed that the data had significant differences and statistical significance(t treatment group=-9.304,t control group=-7.271,both P<0.05).Compared between the groups,the data differences between the two groups were statistically significant(t=-3.124,P<0.05);After two treatment cycles,the CMT of the two groups decreased.Compared with the two groups of 1 and 2 treatment cycles,the difference was statistically significant(t treatment group=-9.631,t control group=-6.148,both P<0.05).Compared between the groups,the difference was statistically significant(t=-5.613,P<0.05).The degree of decline in the treatment group was better than that in the control group;After 3 treatment cycles,the CMT of the two groups continued to decline.Compared with the 2 and 3 treatment cycles of the two groups,the data differences were statistically significant(t treatment group=-5.971,t control group=-3.839,both P<0.05).Compared between the groups,the differences were statistically significant(t=6.871,P<0.05);4.In terms of systemic symptom improvement,the baseline of TCM syndrome score in the pre-medication treatment group is 18.96±4.35(`x±s),and the baseline of TCM syndrome score in the control group is 17.53±4.47(`x±s).After statistical analysis,there is no significant difference between the two groups of data(t=1.36,P>0.05),which is comparable;The syndrome score of the treatment group decreased significantly after 3 treatment cycles compared with before treatment.After statistical analysis,there was a significant difference between the two groups of data results and there was statistically significant(Z=7.151,P<0.05).After 3 months of follow-up,the syndrome score increased.After statistical analysis,the data had no significant difference and there was no statistically significant(P>0.05).for control group,the syndrome scores Compared with the before and after treatment and after 3 months of follow-up showed no significant changes;5.Effective rate,after 6 weeks of medication,the total effective rate of the treatment group was 86.7%,and the total effective rate of the control group was 62.9%,the difference was statistically significant(c2=4.79,P<0.05).6.The recurrence rate,after 3 months of follow-up,a total of 6patients had recurrence,including 5 patients in the control group,the recurrence rate was 14.3%,OCT showed that the CMT increased(>250μm)after 6 weeks of medication,and 1 patient in the treatment group,The recurrence rate was 2.9%,and OCT showed that CMT increased(>250μm)compared with 6 weeks after treatment.7.Complications,in this clinical study,during the medication and follow-up period,there were 4 cases of elevated intraocular pressure,of which 1 case of high intraocular pressure changed the treatment plan,the rest decreased spontaneously after no special treatment,and all cases had no symptoms.Concurrent glaucoma,uveitis,refractive problems,corneal and conjunctival inflammation.In conclusion:1.Based on the results of this study,compared with conventional PCME prevention and treatment drugs,combined with Jiawei Taohong Wuling Powder in the treatment of diabetic PCME can more effectively improve patients’ vision,reduce CMT,and improve patients’ TCM clinical syndromes.2.Based on the results of this study,compared with conventional PCME prevention and treatment drugs,combined with Jiawei Taohong Wuling Powder in the treatment of diabetic PCME,the recurrence rate was lower,the curative effect was more stable,and the complications were less,and to a certain extent,the glucocorticoid eye drops and the effects of glucocorticoid eye drops were reduced.Toxic effects of non-steroidal anti-inflammatory drugs.3.Based on the results of this study,with the gradual increase of the treatment time,compared with the conventional PCME prevention and treatment,the combination of modified Taohong Wuling powder has more prominent efficacy in the treatment of diabetic PCME,and can more reasonably control the disease progression,thereby shortening the course of the disease,reduce the possibility of further development of diabetic PCME. |
PDF Full Text Request