Effect Of CO₂ Pneumoperitoneum On Intestinal Mucosal Barrier In Patients With Uterine Leiomyoma Complicated With Essential Hypertension

Objective:To investigate the effect of CO₂pneumoperitoneum on intestinal mucosal barrier in patients with uterine leiomyoma complicated with essential hypertension（EH）by laparoscopy.Methods:Twenty patients of uterine fibroids with essential hypertension were included in EH group,and twenty non-hypertensive patients of same case were included in the control group（C group）.Both groups were hospitalized in the department of Obstetrics and gynecology of our hospital from June to December 2019,meeting the surgical indications,and were proposed to undergo percutaneous laparoscopic hysteromyoma resection under general anesthesia.Two groups with conventional anesthesia induction,intravenous inhalation combined anesthesia maintenance.Take for 5 ml of radial venous blood at the 10 minute before anesthesia induction（T₁）,1 hour after pneumoperitoneum release（T₂）,24 hour after pneumoperitoneum release（T₃）.To determine the contents of serum Claudin-1 protein and TNF-αand IL-6 in both groups and to record the recovery time of exhaust function.Results:Compared with the T₁,the TNF-αand IL-6 content of the two groups increased（P<0.05）and the Claudin-1 content decreased（P<0.05）.Compared with the C group,the TNF-αand IL-6 content（P<0.05）and postoperative exhaust function recovery time（P<0.05）were higher than those of the C group（P<0.05）.Conclusion:Gynecological laparoscopic surgery CO₂pneumoperitoneum can strengthen inflammatory response by increasing the release of inflammatory factors and inhibit the expression of intestinal mucosal barrier Claudin-1 protein,which can damage the function of intestinal mucosal barrier in patients,while patients with essential hypertension,intestinal mucosal tolerance decreased,intestinal mucosal barrier damage aggravated.