Analsis Of Skin Prick Results Of 10183 Children With Multi-center Sources Of Allergens In Chongqing Area

Objective: To understand the common allergens,and to provide a reference for the prevention and treatment of allergic diseases in children in Chongqing.Methods: There were 10183 children(6245 males and 3938 females)tested for allergen skin-prick-test results in 6 different hospitals in the urban area of Chongqing and its surrounding districts and counties from January 2018 to June 2020.Results were retrospectively studied and analyzed using the chi-square test/Fisher’s exact test.Results: The positive of more than one allergen detection were 61.40%.The top three positive rates of inhalation allergen in different allergic diseases were bronchial asthma(45.71%),chronic cough(22.79%),allergic rhinitis(16.06%).In bronchial asthma,chronic cough,variant rhinitis,cough variant asthma,conjunctivitis,adenoid hypertrophy,the positive detection rate of inhalation is higher than that of ingestion(p<0.05).The positive detection rate of ingestion in allergic dermatitis is significantly higher than that of inhalation(p<0.05).There were differences in the intensity distribution of positive responses to different inhaled allergens(p<0.05),and the positive responses of house dust mites and dust mites were mainly "+++～++++".There were differences in the intensity distribution of positive reactions to different ingestion allergens(p<0.05),and eggs were mainly positive reactions of "+++～++++".The highest proportion of allergens detected in corn pollen was 6.62%,among the different pollens.The distribution of allergens in different age groups between different genders was statistically different(p<0.05),among which the 3-6 years old group had the highest positive rate in boys and girls compared with the 6-18 years old group,and the difference was statistically significant(p<0.05).The positive detection rate of boys was higher than that of girls(p<0.05).The positive detection rate of inhaled allergens increased with age,and the positive detection rate of ingested allergens was highest within 1 year of age.There was a statistical difference between inhaled and ingested allergens between different quarters(p<0.05),in which the first quarter was lower than the third quarter(p<0.05),and the second quarter was higher than the third quarter(p<0.05),the fourth quarter was lower than the third quarter(p<0.05).Conclusion: The inhaled allergens of children in Chongqing are mainly household dust mites,dust mites,and cockroaches,and the ingested allergens are mainly sea crabs,eggs,and shrimp.The epidemic trend is high in the younger(3-6 years old),male,4-6 months,and it is mainly detected in the form of respiratory disease.This study provide direction for the treatment and prevention of children’s allergen diseases in Chongqing,and has important reference value.