Discussion On Professor Li Yan’s Clinical Medication Rules In The Treatment Of Stable Angina Pectoris Based On Data Mining

Objective: through data mining and analysis of professor li yan’ s medical records of treatment of stable angina pectoris,using traditional chinese medicine inheritance calculation platform,Excel,SPSS 26,IBM SPSS modeler 18.0 and other software,to summarize professor li yan’ s medication rules and clinical experience in the treatment of stable angina pectoris.Methods: Medical records that met the inclusion criteria and exclusion criteria of western medicine in the diagnosis of stable angina pectoris and this study were collected from January 2018 to January 2021 in the Outpatient Department of Professor Li Yan,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine.First-visit information was extracted,professional terms were standardized,and data were entered for analysis.Common syndrome types were extracted.The core drugs treated by Professor Li Yan and the common drug combinations were analyzed using statistical software,and the corresponding tables,columns and drug relationship network were drawn.Result:1.A total of 459 patients were included in the study,including 181 males(39.43%)and 278 females(60.57%),with the minimum age of 45 years and the maximum age of 75 years old,and the high incidence area being between50 and 59 years old.2.From high to low,the frequency of syndrome types was in the order of qi stagnation in chest and kidney syndrome > turbid phlegm retention syndrome > deficiency of both qi and yin syndrome > stagnation of heart blood syndrome > cold coagulation in heart and pulse syndrome > deficiency of heart and kidney yin syndrome > deficiency of heart and kidney yang syndrome.3.The total usage frequency of 181 Chinese medicinals was 8094 times through statistical analysis,and the first 10 times were Rhizoma Corydalis >Radix Glycyrrhizae > Radix Astragali seu Hedysari > Radix Angelicae Sinensis > Rhizoma Chuanxiong > Caulis Spatholobi > Ramulus Cinnamomi >Os Draconis > Concha Ostreae > Radix Bupleuri.4.According to the statistical analysis of the nature,taste and meridian tropism of drugs,the drug taste from high to low was sweet drug > bitter drug > pungent drug > salty drug > sour drug;The drug properties were as follows: warm drugs > neutral drugs > cold drugs > cood drugs > hot drugs from high to low.The meridian tropism ranged from high to low from heart meridian,liver meridian,lung meridian,spleen meridian,stomach meridian,kidney meridian,gallbladder meridian,large intestine meridian,bladder meridian,small intestine meridian,sanjiao meridian,and pericardium meridian.5.From high to low,the efficacy of the drugs was ranked as follows:blood-activating and stasis-resolving herbs > deficiency-reinforcing herbs >tranquilizer herbs > exterior-resolving herbs > phlegm-resolving,cough-relieving and asthma-relieving herbs > diuretic and dampness-infiltrating herbs > heat-clearing herbs > liver-calming and wind-calming herbs > qi-regulating herbs > rheumatism-dispelling herbs >digestion-promoting herbs > astringent herbs > resuscitation-inducing herbs >dampness-resolving herbs > purging herbs > warming herbs > hemostasis herbs.6.Eight groups of commonly used herbs were drawn,which were(1)Concha Ostreae and Os Draconis;(2)Radix Platycodi and Rhizoma Corydalis;(3)Os Draconis and Rhizoma Corydalis;(4)Rhizoma Corydalis,Radix Angelicae Sinensis and Radix Astragali;(5)Caulis Spatholobi and Rhizoma Corydalis;(6)Radix Angelicae Sinensis and Fructus Schisandrae Chinensis;(7)Rhizoma Ligustici Chuanxiong and Radix Puerariae;(8)Herba Hedyotis,Rhizoma Polygoni Cuspidati,Herba Patriniae,and Fructus Ligustri Lucidi.7.Four core prescriptions were obtained.Prescription 1: Radix Bupleuri,Ramulus Cinnamomi,Radix Platycodi,Os Draconis,Concha Ostreae,Rhizoma Corydalis,and Radix Angelicae Sinensis;Prescription 2: Rhizoma Corydalis,Fructus Trichosanthis,Bulbus Allii Macrostemi,Caulis Spatholobi,Rhizoma Ligustici Chuanxiong,Poria,and Radix Puerariae;Prescription 3:Radix Pseudostellariae,Fructus Schisandrae Chinensis,Rhizoma Corydalis,and Radix Angelicae Sinensis;Prescription 4: Rhizoma Corydalis,Rhizoma Ligustici Chuanxiong,Radix Angelicae Sinensis,Radix Salviae Miltiorrhizae,Radix Astragali,Caulis Spatholobi,and Radix Puerariae.Conclusion:1.The high incidence age of 1.SAP is 50–59 years old,and more women than men.2.The main syndromes are qi stagnation,cardiothoracic stagnation,turbid phlegm obstruction,deficiency of both qi and yin,and heart blood stasis3.With respect to medication,the principle of promoting blood circulation for removing blood stasis was adopted.The main ingredients of the medication were sweet,bitter and pungent herbs.The properties of the medication were warm,mild and cold.The majority of the medication were transferred to the heart,liver,lung and spleen meridians.The core drugs were Rhizoma Corydalis,Radix Astragali seu Hedysari,Radix Angelicae Sinensis,Rhizoma Ligustici Chuanxiong,Caulis Spatholobi,Ramulus Cinnamomi,Os Draconis,Concha Ostreae and Radix Bupleuri.4.Core prescriptions of each syndrome type: Qi stagnation and cardiothoracic syndrome: Radix Bupleuri,Ramulus Cinnamomi,Radix Platycodi,Os Draconis,Concha Ostreae,Rhizoma Corydalis,and Radix Angelicae Sinensis;Rhizoma corydalis,fructus trichosanthis,bulbus allii macrostemi,caulis spatholobi,rhizoma ligustici chuanxiong,poria,and radix puerariae lobatae in the phlegm turbidity middle stagnation syndrome;Qi-yin deficiency syndrome: Radix Pseudostellariae,Fructus Schisandrae Chinensis,Rhizoma Corydalis,and Radix Angelicae Sinensis;Heart blood stasis syndrome: Rhizoma Corydalis,Rhizoma Ligustici Chuanxiong,Radix Angelicae Sinensis,Radix Salviae Miltiorrhizae,Radix Astragali,Caulis Spatholobi,and Radix Puerariae.5.The main treatment idea is to nourish liver and soften heart,resulting in wood-fire interaction.Toxin transformation of phlegm and blood stasis combined with purging and clearing;Taking care of spleen and stomach,replenishing qi and nourishing blood;Identify the etiology carefully and use the drug prudently.