Clinical Observation Of Detoxification Of Jiedu Qingying Decoction In The Treatment Of Erythroderma Psoriasis (Fire Poison Blazing Type)

Objective:Observe the clinical effect and safety of detoxification Qingying soup in the treatment of erythroderma psoriasis(fire poison blazing type),explore its therapeutic mechanism,and better promote the clinical application of Traditional Chinese medicine decoction.Method:Using the clinical randomized,positive control,double-blind experimental method,including patients with fire poison blazing erythroderma psoriasis who meet the diagnostic criteria of Western medicine for erythroderma and the standards of TCM dialectical analysis,in terms of grouping,the experimental subjects are randomly classified into the treatment group and the control group through the random number table.The control group was given oral proprietary Chinese medicine compound Qingdai capsules.The observation time points were weeks 2,4,6 and 8,and the total course of treatment was 8weeks.According to the Guidelines for Clinical Research of New Drugs in Chinese Medicines(Trial Implementation),the improvement of clinical body surface area and disease severity scores before and after treatment,namely PASI score,dermatological quality of life score index(DLQI)and TCM syndrome score(self-proposed)was statistically analyzed by SPSS software to evaluate the efficacy.Result:1.The actual enrollment of 70 cases,the completion of the total treatment cycle of 68 cases,including 35 cases in the treatment group,33 cases in the control group,2 cases of shedding,35 cases of final treatment group,33 cases of control group were included in the statistical analysis.2.Among the 1.70 enrolled subjects,2 people in the experimental group fell off,and the final experimental subjects were 68 people.3.There were 35 people in the experimental group and 33 people in the control group.In terms of general data such as sex,age and disease course,the two groups of experimental subjects were comparable,both(P>0.05)4.Pending treatment termination,in terms of total effective rate(ORR),the control group and the experimental group were 91.43% and 78.79% respectively;In terms of the manifestation rate indicator,the two groups were 91.43% and 78.79% respectively.Comparing these two indicators with the results of the two groups is P>0.05,that is,there is no obvious difference.5.The clinical improvement rate of 8w in the detoxification Qingying Soup group(treatment group)and the compound Qingdai capsule group(control group)was 88.57% and78.78%,respectively,and there was no obvious statistical difference between the groups(P>0.05).6.After the intervention was over,in terms of PASI score,the results of the pasi score were P > 0.05,that is,there was no obvious difference;the pasi score comparison result before and after the intervention of the two groups was P < 0.01,showing a significant difference.At the end of the intervention,in terms of DLQI scores,the results of the comparison of the two groups were P>0.05,that is,there was no obvious difference;on this indicator,the results of the two groups before and after the intervention were P<0.01,and there were significant differences.After the intervention is over,in terms of TCM syndrome points,the result of comparing the two groups is P>0.05,that is,there is no clear difference.