| Research purposes: In this study,from October 2019 to October 2021,the patient’s condition data were collected in the outpatient department and inpatient department of respiratory department of the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,which was consistent with the diagnosis of chronic obstructive pulmonary disease(COPD)with lung and kidney qi deficiency syndrome in stable stage.Including general information such as age,sex,course of disease,TCM symptom score,self-assessment test questionnaire(CAT questionnaire)for COPD patients,BODE index,and related indexes of lung function,such as therapeutic indexes such as forced expiratory volume FEV1 in the first second,estimated FEV1% of FEV1,rate FEV1/FVC% in one second,number of acute attacks,and safety indexes such as alanine aminotransferase,serum creatinine,etc.A 180-day research on TCM comprehensive rehabilitation of lung and kidney qi deficiency syndrome in stable COPD was conducted based on the theory of "preventing disease" and "health maintenance".The data of the subjects were statistically analyzed,and the effectiveness and safety of the research were summarized to provide scientific basis for TCM comprehensive treatment in stable COPD for reference.Research methods: Seventy-two subjects who met the inclusion and exclusion criteria were stochastic divided into a TCM comprehensive rehabilitation group(hereinafter referred to as the treatment group)and a control group.Both groups were given routine basic medicine treatment according to their needs,and health education and regular follow-up guidance were given when they joined the group.The treatment group publicized the principle of TCM diet regimen on the basis of the control group.The TCM prescriptions with the effects of relieving asthma,eliminating phlegm and tonifying lung and kidney were added.Traditional chinese medicine breathing exercises were added.After 180 days,the TCM symptom score,CAT score,BODE index,the number of acute exacerbations and lung function-related indicators were collected.Safety indicators such as liver and kidney function were statistically analyzed using spss25.0 software using Chi-square test,independent sample t test,Wilcoxon signed rank test and Mann-Whitney test.Research result:1.Distribution of baseline data: 72 cases were collected in this study,including 36 cases in the treatment group,36 cases in the control group,4 cases dropped in the control group.There was no significant difference in sex,age,course of disease,and comparison of western medicine maintenance drugs(P > 0.05).There was no significant difference in TCM symptom score,CAT score,BODE index and related indexes of lung function between the two groups(P > 0.05).2.During the observation period,after the management of the two groups,the difference of TCM syndrome scores between the two groups was statistically significant(P < 0.05),and the improvement of TCM syndrome scores in the experimental group was better than that in the control group.The scores of TCM symptoms in the two groups before and after management were compared,and the difference was statistically significant(P < 0.01),suggesting that the TCM clinical symptoms in the control group had no obvious improvement during the treatment period,while the TCM clinical symptoms in the experimental group were significantly reduced.3.During the observation period,the difference of CAT scores between the two groups after management was statistically significant(P < 0.05),and the improvement of CAT scores in the experimental group was better than that in the control group.Before and after the management,the CAT scores of the two groups were compared within the group.The CAT scores of the control group increased,and the difference was statistically significant(P < 0.05).The CAT scores of the experimental group were significantly improved(P < 0.01).It is suggested that during the treatment period,the clinical symptoms,daily living ability and other life quality evaluation indexes of the experimental group were significantly improved.4.There was no significant difference in BODE index between the two groups during the observation period(P > 0.05).There was no significant difference within the control group(P > 0.05).The BODE index of the treatment group was significantly decreased as compared with that before management(P < 0.01).After discussion,it was speculated that the BODE index of subjects in the treatment group was significantly increased as compared with that before,which might be related to the increased compliance of subjects affected by such factors as TCM health promotion and education;Or that improvement of disease awareness,the homology of medicine and food base on TCM syndrome differentiation,and the promotion of TCM lung rehabilitation program.It indicated that the TCM comprehensive rehabilitation program was helpful for the patients’ motor ability and clinical symptoms,which was consistent with the conclusion of the COPD lung rehabilitation study conducted by Ren et al.The 180-day TCM comprehensive treatment plan lasted for a short period of time and did not significantly improve the respiratory tract state and nutritional state of patients with stable COPD,which might be one of the reasons why the difference between the groups was not statistically significant.5.During the observation period,the number of acute exacerbations in the treatment group was significantly improved as compared with that in the control group(P < 0.01),indicating that comprehensive rehabilitation in traditional Chinese medicine could reduce the risk of acute exacerbation of COPD and improve the prognosis.It should be noted that acute episodes of COPD were season-related,and subjects were enrolled in all four seasons,with the observation period of 180 days,which had some influence on the conclusion of acute exacerbation evaluation.6.During the observation period,the FEV1,FEV1,and FEV1/FVC% values of the two groups after bronchodilator inhalation showed no statistical difference compared between and within the group(P > 0.05),suggesting that the lung function-related indicators in the TCM comprehensive rehabilitation program group and the control group had no decrease or improvement trend.7.During the treatment period,GPT,aspartate aminotransferase and creatinine in the two groups were not statistically significant(P > 0.05),suggesting that the comprehensive rehabilitation program in traditional Chinese medicine was safe and reliable in the treatment of stable COPD without liver and kidney function damage.Conclusion:The TCM comprehensive rehabilitation program can improve the TCM symptoms of lung-kidney qi deficiency in stable COPD.Improving the health-related quality of life of such patients;It is feasible to reduce the risk of acute exacerbation with less adverse reactions. |
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