Clinical Application Of Jigsaw Puzzle Training Combined With SSRIs In Patients With Moderate-grade Depression

Background:As the most common mental disorder in the world,major depressive disorder(MDD)causes damage in the cognitive field and is difficult to treat.Therefore,it is urgent to explore a valuable treatment.Objective:To evaluate the value of selective serotonin reuptake inhibitors(SSRIs)combined with jigsaw puzzle training in the treatment of moderate MDD patients.Methods:According to the relevant diagnostic criteria for MDD in the 10th edition of the international classification of diseases,88 patients with moderate MDD were admitted to Qingdao mental health center in Shandong Province from September 1,2020,to December 31,2021,were selected as the research objects.The randomized stratified sampling method was used to group them,and a single-blind experiment was conducted.The number of cases included in the experimental group was 42(18 males and 24 females),and the number of cases in the control group was 46(20 males and 26 females).In the next 6 weeks,the patients were treated with conventional SSRIs drugs and jigsaw puzzle training.The two groups were evaluated with a self-made general condition research table,Hamilton Depression Scale(HAMD),and other scales.An independent sample t-test was used for the comparison between the experimental group and the control group,and P<0.05 represented the statistical difference.Results:(1)There was no significant difference between the experimental group and the control group in terms of age,sex,the proportion of the corresponding composition,smoking,long-term alcoholism,years of education,the average total course of the disease,the adverse reaction rate of total sleep drugs,and utilization rate of non-benzodiazepine sleep drugs(P>0.05).(2)There was no significant difference in HAMD scores between the experimental group and the control group before the intervention(P>0.05);After the intervention,there was a significant difference in HAMD scores between the two groups(P<0.05);There were significant differences in HAMD scores between the two groups before and after treatment(P<0.05).(3)There was no significant difference between the experimental group and the control group(P>0.05);After the intervention,there was a significant difference between the two WCST groups(P<0.05);There was a significant difference between the two groups before and after treatment(P<0.05).(4)There was no significant difference between the experimental group and the control group in the score of the brief visual-spatial memory test revised(BVMT-R)before intervention(P>0.05);After the intervention,there was a significant difference in BVMT-R scores between the two groups(P<0.05),and there was a significant difference in BVMT-R scores between the two groups before and after treatment(P<0.05).(5)There was no significant difference between the experimental group and the control group in verbal fluency test(VFT)scores before intervention(P>0.05);After the intervention,there was no significant difference in VFT scores between the two groups(P>0.05);There were significant differences in VFT scores between the two groups before and after treatment(P<0.05).Conclusion:(1)The results showed that SSRIs combined with jigsaw puzzle training for 6 weeks could better improve the anxiety and depression,executive function,and visual-spatial working memory of MDD patients than SSRIs alone;However,there was no significant difference between SSRIs combined with jigsaw puzzle training for 6 weeks and SSRIs alone in improving verbal working memory in MDD patients.(2)Jigsaw puzzle training can be used as one of the non-drug treatment methods for MDD patients.