| Objective: "infective post-infective spleen deficiency syndrome" is a new disease name of integrated traditional Chinese and Western medicine first proposed by Professor Meng Zhongfa.It has a high clinical incidence and a long course of disease,and has a great impact on the normal physical and intellectual development of children.At present,western medicine mainly adopts oral intestinal microflora regulator and symptomatic treatment for such cases,but the comprehensive efficacy in improving the clinical symptoms,especially the signs of post-infection spleen deficiency syndrome is not ideal.Based on the holistic concept of TRADITIONAL Chinese medicine,this study observed the clinical efficacy of Jianpi Daozhi Mixture in the treatment of children with post-infective spleen deficiency syndrome,compared the oral clostridium caseinate enterococcus triplex viable tablets,objectively evaluated the efficacy of the two groups of methods,and explored the feasibility of jianpi Daozhi mixture in the application of post-infective spleen deficiency syndrome.In order to provide more evidence and ideas for the clinical treatment of the syndrome,the correlation between spleen deficiency syndrome caused by infection and low-grade inflammation was investigated.Research Methods: In this study,104 children with post-infected spleen deficiency syndrome were collected and randomly divided into two groups.The experimental group 52 patients were treated with oral Jianpi Daoxi mixture,and the control group 52 patients were treated with oral Clostridium caseinate enterococcus triplex viable tablets,and the observation period was 2 weeks(one course).Using SPSS25.0 statistical software respectively on two groups of three or less age < 7 years old,7 years old or less two different age groups of children aged 12 or less two weeks ago after treatment of TCM syndrome integral,hemoglobin(HGB),neutrophil percentage(NEUT %),white blood cell count(WBC)and c-reactive protein(CRP),type of saliva immune globulin A(s Ig A)concentration,salivary amylase(s AA)activity and total response rate were statistically evaluated.Results: 104 cases were planned to be collected in this study,and a total of 95 cases were actually completed,including 48 cases in the experimental group and 47 cases in the control group.Among them,32 cases in the experimental group and 29 cases in the control group were 3 years old ≤ 7 years old,and 16 cases in the experimental group and 18 cases in the control group were 7 years old ≤12 years old.There were 9 cases of abscission,4 cases in experimental group and 5 cases in control group,respectively.Before treatment,gender,age,TCM syndrome score,HGB,NEUT%,WBC,CRP,salivary s Ig A concentration and s AA activity of children in experimental group and control group were compared respectively,all of which were P > 0.05,indicating comparability.1.TCM syndrome score comparison(1)Total score of TCM syndromes: After treatment,the total score of TCM syndromes of the two groups of children at both ages decreased significantly compared with before treatment,and the intra-group comparison was ALL P < 0.05.After treatment,the total score of TCM syndromes in the experimental group was lower than that in the control group(P <0.05),suggesting that the experimental group was superior to the control group in improving the clinical symptoms and signs of TCM in the two age groups.(2)Single score of TCM syndromes: after treatment,each single score of TCM syndromes in both groups was lower than before treatment,and the intra-group comparison was ALL P < 0.05.After treatment between the groups,for the comparison of anorexia and abnormal stool syndrome,the experimental group and the control group at the two ages of the same level of score reduction,both P > 0.05,suggesting that the experimental group and the control group in the two ages of the improvement of anorexia and abnormal stool situation in children are similar efficacy;For the comparison of symptoms of fatigue and abnormal complexion,the score of the experimental group was lower than that of the control group at both ages(P < 0.05),suggesting that the efficacy of the experimental group in improving symptoms and signs of fatigue and abnormal complexion was better than that of the control group.2.Comparison between HGB and NEUT%(1)HGB: After treatment,the level of HGB in children of both ages and groups was increased compared with that before treatment,and the intra-group comparison was ALL P <0.05.After treatment,HGB in the experimental group was higher than that in the control group(P < 0.05),indicating that the effect of the experimental group was better than that of the control group in terms of improving the level of HGB and improving anemia.(2)NEUT% : After treatment,NEUT% levels in both groups of children in both ages decreased,and intra-group comparisons were all P < 0.05.After treatment,NEUT% in the experimental group was lower than that in the control group(P < 0.05),suggesting that the therapeutic effect in the experimental group was better in improving the degree of inflammation.3.Comparison of WBC and CRP(1)WBC: before treatment,the average WBC level of children in the experimental group was 8.08×109/L,among which,the average WBC level of children aged 3 ≤ 7 was 8.19×109/L,and that of children aged 7 ≤12 was 7.86×109/L.The average WBC level in the control group was 7.88×109/L,and the average WBC level in children aged 3 ≤ 7 was7.73×109/L,and that in children aged 7 ≤12 was 8.11×109/L.The average WBC level of95 children collected in the two groups before treatment was 7.78×109/L,which was on the high side of the normal range of WBC regardless of the average WBC level of single group,age group or the total WBC level of the two groups,exceeding the threshold range of WBC elevation in low-grade inflammation(> 6.0-6.8×109/L).After treatment,WBC levels in both groups and at both ages were improved to a certain extent,and intra-group comparison between the two groups and at both ages was P < 0.05.The WBC of the experimental group was lower than that of the control group at both ages(P < 0.05),suggesting that the experimental group was better than the control group in alleviating low inflammatory response.(2)CRP: In the experimental group,the median(first and third quartile)of CRP level before treatment,namely M(Q1,Q3),was 1.93(0.98,2.99),and the M(Q1,Q3)of CRP level before treatment in the children aged 3 ≤ 7 years was 1.86(0.17,2.95).CRP levels in children aged 7 ≤12 years were 2.37(1.26,3.04)before treatment(M(Q1,Q3);In the control group,the M(Q1,Q3)of CRP level before treatment was 1.72(0,3.15),in which the M(Q1,Q3)of CRP level before treatment was 1.72(0,3.38)in children aged 3 ≤ age < 7,and 1.81(0,2.87)in children aged 7 ≤ age ≤12.The CRP level M(Q1,Q3)of 95 children collected in the two groups before treatment was 1.82(0,2.99),which was slightly elevated according to the recommendations of the American heart association and the centers for disease control and prevention(1mg/L < CRP < 3mg/L).However,it did not reach the CRP level of low inflammation(3mg/L < CRP < 10mg/L).After treatment,CRP levels in both groups were reduced,and the intra-group comparisons were all P < 0.05.Comparison between the two groups showed that the CRP levels of the experimental group and the control group were similar(P > 0.05),suggesting that the therapeutic effects of the experimental group and the control group were similar in improving the CRP level of the children in the two ages.4.Comparison of saliva s Ig A concentrationsAfter treatment,the concentration of s Ig A in saliva increased in both groups(P < 0.05).After treatment,the level of s Ig A in saliva of experimental groups was higher than that of control group(P < 0.05),suggesting that the therapeutic effect of experimental groups was better than that of control group in the enhancement of mucosal immune function and improvement of low-grade inflammation.5.SAA activity comparisonAfter treatment,s AA activity decreased in both groups(P < 0.05).After treatment,the activity of salivarium s AA in experimental groups was lower than that in control group(P <0.05),suggesting that the efficacy of experimental groups was better than that of control group in improving the status of spleen deficiency in children with post-infection spleen deficiency syndrome.6.Total efficiency comparisonAfter treatment,the total effective rate of 3 ≤ age < 7 years old children in experimental group: 96.8%,control group: 82.7%;The total effective rate of children aged 7≤12 years was 93.7% in the experimental group and 83.3% in the control group.The total effective rate was 95.8% in experimental group and 87.2% in control group.After treatment,the total effective rate of 3 ≤ 7 years old children was compared,P < 0.05,suggesting that the therapeutic effect of the experimental group was better than the control group.The total effective rate of 7 ≤12 years old children was compared,P > 0.05,suggesting that the efficacy of the experimental group and the control group was similar,which may be related to the relatively small number of cases collected in this age group.The overall total effective rate was compared,P < 0.05,indicating that the therapeutic effect of experimental group was better than that of control group.In conclusion,we believe that jianpi Daozhi mixture is effective in treating post-infective spleen deficiency syndrome in children.Research Conclusions:1.Oral Jianpi Daozhi Mixture has definite efficacy in the treatment of post-infective spleen deficiency syndrome in children,and the clinical efficacy of Jianpi Daozhi mixture is better than clostridium caseinate enterococcus triplex viable tablets.2.The spleen lead lag mixture can better improve the infection pixu(spleen deficient)syndrome due to infection of spleen deficiency of symptoms and signs,especially in improving the body tired weakness,face and other common main symptoms and signs has definite effect,at the same time,also can better improve the level of children HGB,correction of anemia,lower levels of the body inflammation,strengthen the function of mucosal immune,It is worthy of application and promotion to adjust children’s constitution and improve their quality of life.3.There may be a certain correlation between spleen deficiency syndrome and low-grade inflammation in children after infection.Oral Jianpi Daozhi Mixture can improve low-grade inflammation. |
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