The Clinical Research Of Bushen Huoxue Decoction On Mild Cognitive Impairment Of White Matter Lesions With Cerebral Small Vascular Disease

Objective: By using the Fazekas scale score to assess the progress of white matter lesions in cerebral small blood vessel disease,the relationship between the Fazekas scale score and clinical symptoms and neuropsychological scale scores,the efficacy of Bushen Huoxue Decoction in the treatment of cerebral leukopathy with mild cognitive dysfunction in cerebral small vessel disease was evaluated,and the safety of its medication was evaluated,aiming to provide a basis for the treatment of white matter lesions with mild cognitive dysfunction with the Bushen Huoxue Decoction,and to explore its related mechanisms.Methods: From August June 2020 to November 2020 with white matter lesions with mild cognitive dysfunction with syndrome of kidney deficiency and blood stasis who attended the outpatient clinic of the Second Department of Encephalopathy(Neurology)of the affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine were selected as research subjects,and 70 patients who met the diagnostic criteria were screened,randomly grouped into observation and control group,and general demographics and patient disease data were collected.The two groups of patients cooperated in the treatment of Citicoline Sodium Capsules by adding or Bushen Huoxue Decoction to the control group while the control group took Citicoline Sodium Capsules on the premise that the basic Western treatment did not change.The duration of the medication is 12 weeks,and after 1 year as an observation time,we observed the changes in the scoring changes of the two groups before and after the administration of the hematological indicators,oriental medicine symptom integration,TUG quantity table,PSQI quantity table,OABSS quantity table,Mo CA quantity table,and Fazekas quantity table,and monitoring the related safety indicators to mark all adverse events.Record and collect clinical data,classify it,then import a database,process it with SPSS25.0 statistical software,and analyze the related results.Outcome:(1)There was no significant difference in baseline data between the two groups,including age,sex,years of education,history of tobacco and alcohol,past history,hematological indexes,TCM syndrome scores,Mo CA,TUG,OABSS,PSQI and Fazekas scale scores(P>0.05).(2)After treatment: the difference of TCM,Mo CA,the difference of TUG,PSQI,OABSS,DWML syndrome scores in the observation group and the control group were significantly different from those before treatment(P<0.05),the TCM scores,TUG,the total scores of Fazekas and PVWML scores in the observation group and the control group were no significantly different from those before treatment(P>0.05).(3)Comparison before and after treatment in the observation group: TCM syndrome scores,Mo CA,TUG,PSQI,and OABSS were statistically significant(P<0.05);the total score of Fazekas,PVWML score and DWML score were not statistically significant(P>0.05).(4)Comparison before and after treatment in the control group: the TCM syndrome scores,Mo CA,TUG,PSQI and DWML scores were higher than before,and the difference was statistically significant(P<0.05).(5)Overall Efficacy: There were statistical differences in MOCA score,TCM Syndrome score,and Effectiveness Index between observation group and control group(P<0.05).(6)Cerebral small blood vessel disease as a whole is studied,there were statistical differences in UA in patients with different severities of WMLs(P<0.05).And the total Fazekas Scale score was inversely correlated with the MOCA score.The relationship was positively correlated with the TCM syndrome integral and TUG were statistically significant(P<0.05).After a multivariate ordered logistic regression analysis,history of Coronary artery disease was found to be an independent risk factor for WML(P<0.05).(7)Safety: There was no statistical difference(P>0.05)before and after the intervention,including the three major routines,liver and kidney function and electrocardiogram,and no adverse drug reactions.Conclusion:(1)The treatment of Bushen Huoxue Decoction is safe and effective.(2)Bushen Huoxue Decoction can significantly improve the cognitive function,gait,sleep and urinary symptoms of patients with CSVD and white matter lesions with MCI,and significantly improve the symptoms and signs of traditional Chinese medicine.(3)In this study,there are differences in UA values in patients with WMLs of different severitiesit,and was found that the higher Fazekas scale score of WMLs and MCI,the lower the Mo CA score,and the higher Fazekas scale score,the higher the TCM syndrome score,PSQI,TUG,OABSS score.Through this clinical study,it is found that the application of Bushen Huoxue Decoction intervention to alleviate the clinical manifestations of patients with cerebral small blood vessel disease and white matter lesions should be further studied and observed...