| Objective : By detecting cervical human papilloma virus(HPV)and vaginal microecology in pregnant women,to understand the characteristics of HPV infection during pregnancy and its impact on vaginal microecology,to explore whether HPV infection increases adverse pregnancy outcomes,and to improve adverse pregnancy outcomes provide new evidence;Methods:From July 2020 to March 2021,100 pregnant women with HPV infection who underwent prenatal examination in the obstetric outpatient department of the Affiliated Hospital of Inner Mongolia Medical University and gave birth in this hospital during the period from July 2020 to March 2021 were selected as the case group,and 100 cases with negative HPV results were selected.Pregnant women were used as a control group,and the vaginal secretions of all pregnant women were collected before delivery to detect vaginal p H value,pathogenic microorganisms,etc.,and track the pregnancy outcomes of the two groups of pregnant women.Results:(1)Comparison of general data,there was no significant difference in age,gravidity,smoking history and education between the two groups(P>0.05).(2)Comparing the vaginal microecological conditions between the HPV-positive group and the control group,the vaginal p H>4.5 and the composition ratio of vaginal microecological imbalance in the HPV-positive group were significantly higher than those in the control group,and the difference was statistically significant.(3)In this study,there were 68 HPV-positive pregnant women with microecological imbalance,including 19 cases(27.9%)with functional decline,12 cases(14.7%)with bacterial flora inhibition,29 cases(42.6%)with BV,and 7 cases with VVC(10.3%),2 cases of TV(2.9%),and 1 case of other(1.5%);a total of 30 cases of HPV-negative pregnant women with microecological imbalance,including 3 cases of functional decline(10.0%),and 10 cases of bacterial flora inhibition(33.3%),6 cases of BV(20.0%),8 cases of VVC(26.7%),2 cases of TV(6.7%),and 1 case of the other(3.3%).The function of Lactobacillus decreased and the infection rate of BV was significantly higher than that in the HPV negative group(P<0.05).There was no statistical significance in TV,VVC and bacterial group inhibition ratio between the two groups(P>0.05).(4)There was no significant difference in the mode of delivery between the HPV positive group and the negative group(P>0.05).(5)In this study,there were 22 cases of premature rupture of membranes,11 cases of premature birth,3 cases of puerperium infection,5 cases of postpartum hemorrhage,and 0 cases of fetal growth restriction in the HPV-positive group,and the HPV-negative group with premature rupture of membranes 14 cases,4 cases of premature birth,2 cases of puerperal infection,3 cases of postpartum hemorrhage,0 case of fetal growth restriction,200 cases of observation group.There was no significant difference in the rate of postpartum hemorrhage(P>0.05).There were 0 cases of fetal growth restriction in both groups.(6)The incidence of HPV-positive pregnant women with microecological imbalance was 14.7%(10/68),the incidence of premature rupture of membranes was 27.9%(19/68),the incidence of puerperal infection was 4.4%(3/68),and the incidence of postpartum hemorrhage The incidence of fetal growth restriction was 0(0/68);the incidence of preterm birth in HPV-positive pregnant women with normal microecology was 3.1%(1/32),and the incidence of premature rupture of membranes was 9.4%(3/32),the incidence of puerperal infection was 0(0/32),the incidence of postpartum hemorrhage was 3.1%(1/32),and the incidence of fetal growth restriction was 0(0/32).The pregnancy outcomes between the groups were tested by chi-square,and the incidence of premature rupture of membranes in the microecological imbalance group was significantly higher than that in the normal microecological group,and the differences were statistically significant(P<0.05).There was no significant difference in the bleeding rate(P>0.05),and the number of fetal growth restriction cases in both groups was 0.Conclusion :(1)The results of this study showed that HPV infection during pregnancy had no significant effect on maternal and infant pregnancy outcomes.(2)HPV infection during pregnancy has little relationship with the mode of delivery,and HPV infection is not an indication for cesarean section.(3)HPV infection is closely related to vaginal microecology.Latent infection of HPV virus during pregnancy will destroy the acidic environment of the vagina and increase the incidence of vaginal microecological imbalance,which is a high risk factor for premature rupture of membranes(P<0.05).Therefore,the detection of the lower genital tract during pregnancy should be strengthened to prevent and reduce adverse pregnancy outcomes for mothers and infants;at the same time,prevention work should be vigorously promoted,early detection,early treatment,and pregnancy after cure,to reduce the rate of lower genital tract infection during pregnancy.Improve maternal and infant pregnancy outcomes. |
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