Changes And Clinical Significance Of Plasma CLEC2 And Thrombopoietin Levels In Patients With Chronic Altitude Sickness And Thrombocytopenia

Objective:By detecting the plasma levels of calcium-dependent lectin-like receptor 2(CLEC2)and thrombopoietin(TPO)in patients with chronic altitude sickness and thrombocytopenia,and analyzing their clinical significance,to explore the relationship between chronic altitude sickness and thrombocytopenia Pathogenesis.Methods:Twenty cases of patients living above 2500m above sea level and meeting the diagnostic criteria of chronic altitude sickness with platelets below 100×109/L were selected as the experimental group,and 20 healthy people from the local physical examination center were selected as the control group.ELISA method was used to detect the levels of CLEC2 and TPO in the plasma of the experimental group and the control group.At the same time,the correlation between CLEC2 and TPO in the plasma of the experimental group and the relationship between the platelet level and CLEC2 and TPO in the experimental group were detected.Clinical significance in patients with thrombocytopenia,all data were processed using SPSS22.0 statistical software.Results:1.1.Compared with the healthy subjects(control group),patients with chronic altitude sickness(experimental group)generally have increased serum CLEC2 levels,and the significant P value is close to 0.000<0.05,indicating that the CLEC2 indicators of the control group and the experimental group are significantly different,and The CLEC2 value of the chronic altitude sickness group(14.5545±2.74247)was significantly higher than that of the control group(8.978±1.65705).The significant P value of experimental group 1(platelets between 75-100×10~9/L)and experimental group 2(platelets between 50-75×10~9/L)was 0.002<0.05,indicating that experimental group 1(platelets at 75-100×10~9/L)and experimental group 2(platelets between 50-75×10~9/L)were significantly different,and the clec2value of experimental group 2(15.7580±2.57069)was significantly higher than that of experimental group 1(11.6375±3.12128).2.Compared with healthy people(control group),patients with chronic altitude sickness(experimental group)generally have increased serum TPO levels,and the significant P value is close to 0.000<0.05,indicating the difference between the control group and the experimental group Significant,and the TPO value of the experimental group(1309.7265±230.72121)was significantly higher than that of the control group(636.0119±380.87614).The significant P value of experimental group 1(platelets between 75-100×10~9/L)and experimental group 2(platelets between 50-75×10~9/L)is 0.016<0.05,indicating that experimental group 1 and experimental group 2 The difference was significant,and the TPO value of experimental group 2(1429.5370±203.25948)was significantly higher than that of experimental group 1(1189.9160±197.90356).3.Serum CLEC2 levels and platelet levels in patients with chronic altitude sickness were negatively correlated.Pearson’s correlation coefficient R=-0.45,with a significant P value of<0.05,indicating a significant inverse correlation.4.Serum TPO level and platelet level in patients with chronic altitude sickness were negatively correlated,Pearson’s correlation coefficient R=-0.533,significant P value<0.05,indicating a significant inverse correlation.5.The correlation coefficient of CLEC2 and TPO in patients with chronic altitude sickness is-0.015,indicating that the two are negatively correlated,and the significant P value is 0.949>0.05,indicating that the correlation between CLEC2 and TPO in the experimental group is not significant.Conclusions:1.Compared with healthy people,patients with chronic altitude sickness and thrombocytopenia generally have increased serum TPO levels.2.Compared with healthy subjects,patients with chronic altitude sickness and thrombocytopenia generally have increased serum CLEC2 levels,indicating that the platelets in the peripheral blood circulation of patients with chronic altitude sickness are aggregated,activated,and even thrombosis.3.CLEC2 and TPO in patients with chronic altitude sickness were negatively correlated,that is,the correlation was not significant,which may be related to the hypoxic and low pressure environment.