In recent years,the continuous development of science and technology has promoted the progress of medical technology,and the emergence of new experimental therapies has brought hope for the treatment of various diseases.Chimeric Antigen Receptor T-Cell Immunotherapy(CAR-T)therapy is a new cellular immunotherapy for tumor treatment.It has the opportunity to cure cancer in the future and is a promising treatment method.CAR-T therapy uses patient biological samples to prepare special drugs.This process involves multiple links such as logistics,hospitals,and factories.Therefore,it is necessary to accurately trace the entire process,and at the same time,it is necessary to ensure that the privacy of patients is not leaked.The non-tamperable feature of the blockchain can realize the recording and traceability of data without relying on the trust mechanism,and fully meet the authenticity requirements of the traceability information of the whole process of CAR-T therapy.However,transaction data in traditional blockchains are usually stored and transmitted in plaintext,which has a certain risk of data leakage and is difficult to meet security requirements.Existing blockchain platforms provide two schemes to solve this problem:symmetric encryption mechanism and privacy data mechanism.However,these two mechanisms still have certain defects:the symmetric encryption mechanism can realize the distinction of information rights,but it leads to the problem of a large amount of keys and difficult to maintain and complicated management;the privacy data mechanism can realize the data access control based on the organization,but still There are problems of data leakage and coarse-grained access control.In view of the above problems,a scheme that combines data reversible desensitization and attribute encryption-based CP-ABE algorithm on the Fabric platform is proposed.,according to the full-process information traceability requirements of CAR-T,fully considering data authenticity and security.First of all,through data reversible desensitization processing of personal privacy information,and then through the improvement of Fabric CA to realize the generation and safe distribution of user attribute keys,the transaction information is stored and transmitted through the Encrypt module of the CP-ABE algorithm to realize the storage and transmission of ciphertext.The access control of user attribute set is realized through the Decrypt module of CP-ABE algorithm.This solution can realize the immutability of stored data and user-level access control,and can meet the requirements of data authenticity and security.Finally,based on this scheme,the design and implementation of the traceability system in the medical scene has been completed,and the test proves that the system has good usability and practical application value. |