| Objective: 1.Through the meta-analysis of the literature of randomized controlled clinical trails on the treatment of cardio-renal incontinence with traditional Chinese medicine,this paper discusses the curative effect of traditional Chinese medicine on cardio-renal incontinence,and lays an evidence-based clinical basis for clinical medication.2.Through data mining and analysis,the traditional Chinese medicine compound for treating insomnia from heart and kidney is studied and summarized,which provides referencefor clinical prescription.Methods:1.Meta analysis: The database was searched in Pubmed,Cochrane Library,EBSCO,Web of science,Sinomed,China Journal Full Text Database(CNKI),Vip Chinese Journal of Science and Technology(VIP)database,and Wanfang Medical Journal Full Text Database and the randomized controlled clinical trial of traditional Chinese medicine in treating insomnia with heart kidney incompatibility was conducted until June 1,2022.Two researchers repeated literature screening and data extraction,and reach a consensus respectively,using Rev Man5.3 software completes the statistical analysis.2.Data mining: By searching the literature on trating insomnia from heart and kidney with oral traditional Chinese medicine from January2015 to September 1,2022 in Pubmed,Sinomed,CNKI,Weipu Chinese Sci-tech Journal database and Wanfang Medical Journal Full-text Database.According to the inclusion criteria,prescriptions were screened,databases were established,and high-frequency drug complex network analysis was conducted with SPSS Modeler 18.0 software and SPSS Statistics 26 Correlation and cluster analysis.To demonstrate the medication characteristics and prescription rules of traditional Chinese medicine in treating insomnia from heart and kidney.Results:1.Meta analysis: A total of 11 RCT literatures were included in 820 patients.The observation indexes included overall clinical effective rate、PSQI and TCM syndrome score scale.The results of Meta study showed that 10 literatures adopted fixed effectmodelin the overall clinical effective rate of treating cardiorenal incontinence with traditional Chinese medicine,and the difference was statistically significant(RR=1.16,95%CI[1.08,1.24],P<0.0001).Randomized effect model was used in the scoring of TCM ayndromes in 7 documents,and the difference was satistically significant(MD=-4.91,95%CI[-6.62,-3.56],P<0.001).In 8literatures with PSQI,the randomized effect model was used,and the difference was statistically significant(MD=-2.65,95%CI[-4.41,-0.90],P<0.0001).2.Data mining: A total of 56 articles were included,involving 59 groups of prescriptions,including 127 kinds of traditional Chinese medicines.The total frequency of drug use was 719 times,among which Suanzaoren,Huanglian,Rougui,Gancao,Yuanzhi,Shengdihuang,Shanzhuyu,Shudihuang,Wuweizi,Fuling were in the top ten.Among the included drugs,the drugs with cold,mild and warm natures are used most frequently.Most of the drugs are sweet,bitter and pungent,and most of the effects have the functions of tonifying deficiency,calming nerves and clearing away heat.The highest support of association rule analysis was Huanglian-Rougui,and the drug group was Huanglian-Rougui and Suanzaoren.Six groups of clustering formulas were obtained by cluster analysis.Conclusion:Traditional Chinese medicine is better than western medicine alone in improving clinical effective rate,improving syndromes of traditional Chinese medicine,and reducing Pittsburgh sleep index(PSQI)of insomnia with heart kidney disjunction,which is worthy of clinical recommendation;The traditional Chinese medicine for treating insomnia from the heart and kidney is often sour jujube kernel,coptis chinensis,cinnamon,etc.The core formula often uses Liuwei Dihuang Pill,Tianwang Buxin Pill,etc.The traditional Chinese medicine with the functions of regulating qi and clearing heat,activating blood circulation and removing blood stasis,and tonifying deficiency and tranquilizing the middle can be used for the patients with the long course of disease. |
PDF Full Text Request