Effect Of Huatan Zhuyu On TNF-α And ICAM-1 Levels In Patients With Phlegm-blood Stasis Type Of Hypertension And Mild OSAHS

Objective:We intend to research the clinical potency of Huatan Zhuyu on phlegm-stasis type hypertension and the mild obstructive sleep apnea-hypopnea syndrome.At the same time,We want to explore their inflammatory mechanism.Methods:Among the inpatients in Qingdao Traditional Chinese Medicine Hospital,we choosed 60 patients that the patients complianced with standards.we divided into two groups for the 60 patients.Each group had 30 peoples.Control group:healthy lifestyle education,amlodipine treatment,initial 5mg/time,maximum 10mg/time,if the expected standard is not met,use valsartan 80mg/time,otherwise use multiple drugs in combination according to the medication guidelines to ensure that the blood pressure is up to standard,once a day;The treatment group:health lifestyle education,add HuatanZhuyu therapy on the basis of control group,twice a day.Two groups were treated for 4 weeks.Monitor blood pressure during the experiment,adjust antihypertensive drugs in time to avoid accidents.After 4 weeks,blood pressure,BMI,AHI,minimum blood oxygen,maximum apnea time,average blood oxygen,ESS sleepiness scale,TCM syndrome score,TCM syndrome efficacy,TNFa and ICAM-1 levels were observed before and after treatment in the two groups for statistical analysis.Results:1.Blood pressure level:After treatment,the blood pressure of both groups reached the expected standard,and the antihypertensive effect of the treatment group was more obvious(p<0.01).2.BMI change:After treatment,the body mass index of the two groups went down,and after statistical analysis the differences are meaningless in BMI(p>0.05).3.Sleep respiration monitoring index:After treatment,the AHI and ESS of patients in both groups were decreased,and the minimum and average blood oxygen were increased.The clinical effect of the treatment group was more significant(p<0.01).The longest apnea time decreased without significant difference(p>0.05).4.TCM syndrome integral:After treatment,the TCM syndrome integral for two groups were fall-off,and the discomfort for the treatment group improved clearly(p<0.01).5.Immunoinflammatory index:The levels of serum TNF-α and ICAM-1 in both groups decreased,and the anti-inflammatory effect in the treatment group was more significant(p<0.01).Conclusion:The Huatan Zhuyu therapy of TCM added in simple depressor was better than the simple depressor for the phlegm-stasis type hypertension and mild OSAHS,is better than that of Western medicine alone,and the impression of improving sleep quality and discomfort is obvious surpassed that of antihypertensive therapy alone.At the same time,the treatment of resolving phlegm and removing stasis can reduce the level of inflammatory factors such as TNF-α and ICAM-1,improve the inflammatory reaction in blood vessels,reduce the damage of vascular endothelium,and achieve the purpose of treating OSAHS and hypertension patients.