Clinical Observation On The Treatment Of Acute Ischemic Stroke(Wind Phlegm Stasis Syndrome) With Huatan Tongluo Decoction And In Vitro Cultivation Of Bezoar

Objective:To explore the clinical effect of Niuhuang cultivated by Huatan Tongluo decoction in vitro on acute ischemic apoplexy(syndrome of wind,phlegm and blood stasis),and to evaluate the quality of life and the improvement after treatment.At the same time,explore the adverse reactions and safety of this combination of drugs.Methods:The patients selected in this study were all diagnosed as acute ischemic stroke(wind-phlegm and blood-stasis syndrome)from October 2021 to December 2022 in the Department of Encephalopathy of the Hospital of Integrated Traditional Chinese and Western Medicine of the Southern Medical University.The patients were screened according to the diagnostic criteria of traditional Chinese medicine and western medicine,syndrome type and inclusion and exclusion criteria,including 62 patients.The patients were randomly divided into two groups,31 patients in each group.Because of the exfoliation in vitro of Calculus Bovis group and combined group,60 patients were enrolled.Routine treatment was adopted in both groups.The combined group was treated with Routine Western Medicine and Huatan Tongluo Decoction in combination with outside cultured Calculus Bovis.The Calculus Bovis Bovis Group was treated with Routine Western Medicine and in vitro cultured Calculus Bovis.The method of administration was:in vitro cultured Calculus Bovis(2 times per day,0.15g/time,oral/nasal feeding),Huatan Tongluo Decoction(2 times per day,200ml/time,oral/nasal feeding).The duration of administration was 14 days.Neurological impairment scores,TCM syndrome scores,NIHSS scores,daily living ability(BI index)scores,blood lipids and adverse events were systematically assessed on day 1 and 14 after admission.Results:The results showed that the total effective rate of the combined group was 93.3%and 76.7%respectively(P<0.05).Before treatment,there was no significant difference between the two groups in age,course of disease,sex,underlying disease,infarct site,liver and kidney function and blood lipid index,TCM syndrome score,stroke scale(NIHSS)score and BI index score(P>0.05).The scores of NIHSS and BI were statistically significant(P<0.05).The difference of TCM syndrome scores between the two groups was statistically significant(P<0.05),but not in language,digital paralysis and digital paralysis(P>0.05).Blood lipid index,TCM syndrome score,NIHSS score and BI score before and after treatment were statistically significant(P<0.05).In safety evaluation,there was no significant difference between the two groups(P>0.05).It was proved that Huatan Tongluo Decoction was a safe and effective treatment method.Conclusion:1.Cultivation of Niuhuang in combination with Huatan Tongluo Decoction can improve the TCM syndrome score and NIHSS score as well as the living ability of patients with acute ischemic stroke.2.Huatan Tongluo Decoction combined with cultivation of bezoar in vitro is safe and can reduce adverse events.