Multimodal Fusion Technology For Three-dimensional Reconstruction Of Superior Petrosal Vein And Its Applied Anatomical Research

ObjectiveThe superior petrosal vein(SPV)is a common roadblock vein in posterior fossa surgery,and the superior petrosal vein complex(SPVC)is highly variable.In previous studies,most of the general anatomy was used to analyze the morphology of SPVC.In order to reflect the morphological characteristics of SPV and its adjacent bone structures more objectively and personally,this study applied contrast enhanced magnetic resonance angiography(contrast enhanced magnetic resonance angiography).The multi-modal fusion technology combining magnetic resonance angiography(CE-MRA)and computer tomography(CT)three-dimensional reconstruction of the normal anatomical structure of the SPVC and its surrounding skull.Use 3Dslicer software to measure the distance between the body surface projection of the inner angle of the junction of the sigmoid sinus and the transverse sinus(transverse and sigmoid sinus transition,TSST)from the star point and the mastoid tip,and perform statistical analysis with the relevant parameters in the literature.To evaluate the feasibility of this technology.3D printed the SPV and its adjacent structure model for clinical application and to clarify its significance in clinical and teaching.Methods(1)By adjusting the concentration of the contrast agent,the injection speed of the contrast agent,the start scanning time,etc.,the scanned 3D CE-MRA is judged by the image processing workstation MIP post-processing software to determine the success of the SPVC development.Subsequently,the raw data of 3D CE-MRA and 3D CT were imported into 3Dslicer software.Then,through image registration,threshold segmentation and structure pruning,the data and processes are packaged and saved.Finally,the packaged data of these two modalities are imported together and displayed in 3D fusion at the same time.(2)By importing the multi-modal fusion three-dimensional model into the measurement module,measure the distance between the projection of the TSST inner angle in the posterior fossa and the star point and the tip of the mastoid respectively,and compare them with the relevant parameters of the CTA in the literature.Statistical Analysis.(3)Export the anatomical structure of the multi-modal fusion in STL format,and then export it after smoothing and denoising by Geomagic Freeform sofeware,using photosensitive resin as the material for 3D printing and applying it to clinical surgery guidance.Results(1)SPV and its tributaries,superior petrosal sinus(SPS),sigmoid sinus,transverse sinus,cavernous sinus and other venous structures,as well as internal auditory canal,groove of petrosal sinus and groove of transverse sinus are obtained after multimodal fusion Skull base bony structures,especially bony anatomical landmarks near the petrosal area.(2)In the three-dimensional structure obtained by the multi-modal fusion technology,the distance between the body surface projection of the inner corner of TSST and the star point and the tip of the mastoid and the corresponding standard value of the CTA in the literature are subjected to single-sample t-test.Among them,the distance between the projection point of the TSST inner angle on the surface of the skull and the star point is compared with the relevant standard value of CTA in the literature.The t value is 2.631 and the p value is 0.013.The results are statistically different.The distance between the projection point of the TSST inner angle on the surface of the skull and the tip of the mastoid is compared with the standard value of CTA in the literature.The t value is-1.750 and the p value is 0-089.The results are not statistically different.(3)A case of 3D printing out SPV and its adjacent anatomical structure model for clinical operation guidance.ConclusionThe combination of imaging and 3Dslicer software can vividly display the anatomical structure of multi-modal fusion,and it also has a certain degree of accuracy.The application of 3D printing models in clinical practice is of great significance.Multimodal fusion technology provides new possibilities for the study of anatomical morphology,and can also provide a personalized reference for clinical surgery.