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Clinical Observation On The Effect Of Bushen Zhuanggu Ointment On Postoperative Healing Of Tibiofibular Fracture Of Liver And Kidney Deficiency Type

Posted on:2024-06-04Degree:MasterType:Thesis
Country:ChinaCandidate:S W AnFull Text:PDF
GTID:2544306929476564Subject:Master of Traditional Chinese Medicine
Abstract/Summary:PDF Full Text Request
Objective : In this study,by observing the effect of Bushen Zhuanggu ointment on postoperative healing of tibiofibular fractures with liver and kidney deficiency,the clinical efficacy and safety of Bushen Zhuanggu ointment in the treatment of fractures were objectively evaluated.The clinical efficacy,imaging examination,joint function score and adverse reactions of Xianling Gubao capsule in promoting postoperative healing of tibiofibular fractures were compared,so as to objectively evaluate and preliminarily explore its clinical efficacy and safety,and provide a more reasonable theoretical basis for clinical application.Methods : According to the inclusion criteria of the test,among the patients with tibiofibular fractures(liver and kidney deficiency type)who underwent surgical treatment in the Department of Orthopedics and Traumatology of Rizhao Hospital of Traditional Chinese Medicine from November 2021 to December 2022,the basic information of the patients was recorded after admission.After the diagnosis was confirmed,the informed consent of the patients was obtained.Sixty patients who met the inclusion criteria were randomly divided into treatment group and control group,with 30 cases in each group.According to the development process of fracture injury in traditional Chinese medicine,on the basis of the same ‘early’and‘middle’treatment and postoperative routine treatment,the treatment group was treated with Bushen Zhuanggu ointment orally twice a day,once in the morning and once in the evening,20 g of ointment was taken each time,and 200 ml of warm boiled water was added for 8weeks.The control group was given Xianling Gubao capsule orally,3capsules at a time,twice a day.Each course of treatment was 4 weeks,and a total of 2 courses were observed.The fracture healing time of the two groups of patients from the 7th day after treatment was recorded,and the X-ray Fernandez-esteve callus score of the patients was recorded from four time points(the 2nd week,the 4th week,the 8th week,and the 12 th week).The Johner-Wruhs tibia and fibula fracture healing function scores were evaluated before treatment and at the 2nd and 4th weeks after treatment.The TCM syndrome scores and liver and kidney functions of the two groups of patients before and after treatment were evaluated.SPSS25.0 statistical software was used for statistical analysis of data to obtain efficacy evaluation.Results : 1.In the course of treatment,two patients in the control group fell off due to follow-up failure,and the treatment group did not fall off.After statistical analysis,there was no significant difference in gender,age,fracture site,surgical method and liver and kidney function between the two groups before treatment(P>0.05).2.In terms of fracture healing time:There was a statistically significant difference in the improvement of fracture clinical healing time between the two groups after treatment(P<0.05),and the fracture clinical healing time of the treatment group(9.37±2.04)was significantly faster than that of the control group(11.86 ± 1.95),with a significant difference(P<0.05).3.X-ray callus score : There was no significant difference in X-ray callus score between the two groups before treatment(P>0.05).After 2 to4 weeks of treatment,the callus score of the two groups increased,but there was no significant difference between the two groups(P>0.05).After12 weeks of treatment,the callus line score of the treatment group was significantly higher than that of the control group,with statistical significance(P<0.05).4.Johner-Wruhs tibiofibular fracture healing function score : Compared with before treatment,after 2 weeks and 4weeks of treatment,the difference of tibiofibular fracture healing function score between the treatment group and the control group was statistically significant(P<0.05).The fracture healing function score of the treatment group was significantly better than that of the control group.The total effective rate of the treatment group was 96.6%,and the total effective rate of the control group was 71.4 %.There were no adverse drug reactions in the two groups during the treatment.Conclusion : Clinical studies have shown that Bushen Zhuanggu Ointment can significantly improve the clinical symptoms of traditional Chinese medicine in patients with tibiofibular fracture of liver and kidney deficiency type,promote callus formation,reduce the clinical healing time of fracture,and restore the joint function of patients.The clinical safety is good and the clinical efficacy is definite.In improving the clinical syndromes of traditional Chinese medicine,promoting the formation of callus and reducing the clinical healing time of fracture,Bushen Zhuang...
Keywords/Search Tags:Bushen Zhuanggu Ointment, tibiofibular fracture, Deficiency of liver and kidney type, Clinical study
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