Study On Correlation Between TCM Syndrome And Physicochemi Examination Index In Children With Lobar Pneumonia

Objective: To explore the distribution characteristics of TCM syndrome of children with lobar pneumonia and its correlation with physical and chemical examination indexes,so as to provide evidence for clinical treatment based on syndrome differentiation.Methods: Medical records of 92 children with lobular pneumonia who were hospitalized in the pediatrics department of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from October 2020 to December 2022 were collected,including the mycoplasma infection group and the non-mycoplasma infection group.General data,clinical manifestations,distribution of syndrome elements and syndrome types,physical and chemical examination indexes of the two groups were analyzed and compared by cross-sectional study method.SPSS 25.0 was used for statistical analysis to preliminarily explore the syndrome characteristics and syndrome differentiation of children with lobar pneumonia.logistic regression analysis was conducted to analyze the correlation between mycoplasma infection of children with lobar pneumonia and physical and chemical examination.Results :1.General situation: there were no differences in gender and BMI distribution between MP infection group and non-MP infection group(P>0.05).The median age of MP infection group was higher than that of non-MP infection group(P<0.05),and there was a difference in age distribution between the two groups(P<0.05).The MP infection group was dominated by preschool age and school age,while the non-MP infection group was dominated by infants and pre-school age.The length of hospital stay in MP infection group was longer than that in non-MP infection group,with statistical significance(P<0.05).2.Clinical features: the heat potential and heat course of the MP infection group were higher than those of the non-MP infection group(P<0.05).The MP infection group was dominated by high fever,and the mean fever time was 6.90±2.63 days,while the non-MP infection group was dominated by moderate fever,and the mean fever time was 4.88±2.51 days.There was no significant difference in the degree of cough and asthma and the performance of respiratory sound between the two groups(P>0.05).The imaging lesion sites of this disease were mostly involved in the right lower lobe,and there was no statistical difference in lesion sites and distribution between the two groups(P>0.05).Compared with the non-MP infection group,the proportion of pleural effusion was greater in the MP infection group(P<0.05).In terms of tongue texture distribution,tongue red and tongue red were dominant in MP infection group,while tongue red and tongue tip were dominant in non-MP infection group.In terms of tongue coating distribution,the proportion of thick and greasy tongue coating in MP infection group was larger than that in non-MP infection group.3.TCM syndrome types and syndrome elements: The main core syndrome elements extracted from children with lobed pneumonia were heat,dampness,phlegm,external wind,blood stasis,poison,lung,surface,etc.The occurrence frequency of syndrome elements such as dampness,blood stasis,food accumulation and spleen in MP infection group was higher than that in non-MP infection group(P<0.05).The sequence of syndrome types in MP infection group was syndrome of dampness-heat implication>syndrome of phlegm-heat implication>syndrome of toxic-heat implication>syndrome of wind-heat implication>syndrome of wind-heat implication>syndrome of wind-heat implication>syndrome of toxic-heat implication>syndrome of wind-heat implication>syndrome of toxic-heat implication>syndrome of wind-heat implication>syndrome of toxic-heat implication =syndrome of wind-cold implication.There was no statistical difference in the distribution of syndrome types between the two groups(P>0.05).4.There were statistical differences in the levels of WBC,LDH and DDI among different syndrome types of the disease(P<0.05).The level of WBC was the highest in the syndrome of toxic-heat shutting down lung;the level of LDH in the syndrome of toxic-heat shutting down lung and the syndrome of damp-heat internalization was higher than other syndrome types;the level of DDI in the syndrome of damp-heat internalization and the syndrome of phlegm-heat shutting down lung was higher than other syndrome types;There were no significant differences in the levels of NEU,NEU%,LYM,LYM%,CRP,PCT,PT,APTT,TT and FIB among different syndromes(P>0.05).5.Compared with non-MP infection group,the levels of NEU%,LDH,PT,FIB and DDI in MP infection group were increased,while L% was decreased(P<0.05).6.Logistic analysis showed that LDH was positively correlated with MP infection(OR=1.01,P<0.05).Conclusions :1.The children with MP infection were older and the hospital stay was longer.In the most common age group,the majority of children with MP infection were in the early school age and school age,while the majority of children with non-MP infection were in the early infant and school age.2.The heat potential and heat course of children with MP infection were higher than those of children without MP infection;The proportion of pleural effusion in children with MP infection was higher.The tongue quality of children with MP infection was mainly red and red tongue,while that of children without MP infection was red and red tongue tip.The proportion of thick and greasy tongue coating in children with MP infection was larger than that in children without MP infection.3.The main core syndrome elements of this disease were heat,dampness,phlegm,external wind,stasis,poison,lung and surface.The frequency of dampness,blood stasis,food accumulation and spleen were higher in children with MP infection.4.TCM syndromes in the two groups were mainly syndromes of dampness-heat and phlegm-heat closing lung,and the proportion of dampness-heat syndromes in the children with MP infection was larger,suggesting that MP infection was related to dampness-heat.5.There were statistical differences in the levels of WBC,LDH and DDI among different syndrome types.The WBC level was the highest in the syndrome of toxic-heat shutting down lung,the LDH level increased significantly in the syndrome of toxic-heat shutting down lung,and the DDI level increased significantly in the syndrome of damp-heat connotation and phlegm-heat connotation.6.Compared with the two groups,the levels of NEU%,LDH,PT,FIB and DDI were increased and LYM% was decreased in the children with MP infection.Logistic analysis showed that LDH was positively correlated with MP infection.It is suggested that the inflammatory reaction,hypercoagulability and disease degree of MP infected children are higher than those of non-mycoplasma infected children.