Clinical Efficacy Of Jiangqi Xiaoying Decoction In The Treatment Of Refractory Hyperthyroidism

Objective: To observe the clinical efficacy and safety of Jiangqi Xiaoying decoction in the treatment of refractory hyperthyroidism.Methods: 60 patients who met the inclusion criteria were randomly divided into control group and treatment group,30 cases in each group.In the basic treatment(hyperthyroidism related education,giving patients good psychological counseling,regulating emotion;guide patients with low iodine,high calorie,high protein,high vitamin diet;on the basis of guiding patients to develop a good lifestyle,moderate exercise,avoid staying up late,etc.),the control group was given methimazole tablets orally,and the treatment group was treated with Jiangqi Xiaoying Decoction on the basis of the treatment plan of the control group.In the course of treatment,if tachycardia occurs,propranolol hydrochloride tablets are given;in the course of treatment,if mild liver function damage occurs,diammonium glycyrrhizinate enteric-coated capsules are given;in the course of treatment,if mild leukopenia occurs,leucogen tablets are given.4 weeks for a course of treatment.A total of 3 courses of treatment were observed.The symptom score and FT3,FT4,TSH,TRAb and other medical indicators were compared before and after treatment,and statistical analysis was performed.Results: 1.Comparison of FT3,FT4,TSH and TRAb : intra-group comparison showed that there were significant differences in FT3,FT4 and TSH levels before and after treatment in the treatment group(P<0.01),and there were significant differences in FT3,FT4 and TSH levels before and after treatment in the control group(P<0.05).There were significant differences in FT3,FT4 and TSH levels between the treatment group and the control group after treatment(P<0.01).2.TRAb comparison : intra-group comparison showed that there was a significant difference in TRAb level before and after treatment in the treatment group(P<0.01),and there was a significant difference in TRAb level before and after treatment in the control group(P<0.05);the comparison between the two groups showed that there was a significant difference in TRAb level between the treatment group and the control group after treatment(P<0.01).3.Comparison of symptom scores :Comparison of total symptom scores : Comparison within the group showed that there was a significant difference in the total symptom scores before and after treatment in the treatment group(P<0.01),and there was a significant difference in the total symptom scores before and after treatment in the control group(P< 0.05);the comparison between the two groups showed that there was a significant difference between the treatment group and the control group in improving symptoms(P<0.01).Comparison of individual symptom scores : Comparison between groups showed that there were significant differences between the treatment group and the control group in symptoms such as palpitation,fear of heat,sweating,insomnia and dreaminess,dry mouth,irritability,polyphagia,fatigue,and tremor(P<0.01).There was no significant difference between the treatment group and the control group(P>0.05).4.Comparison of TRAb effective rate between the two groups after treatment : 29 cases in the treatment group,6 cases were markedly effective after treatment,22 cases were effective,1 case was ineffective,the total effective rate was 96.55 %,and the effective rate was 20.69 %.In the control group of 28 cases,after treatment,0 cases were markedly effective,8 cases were effective,20 cases were ineffective,and the total effective rate was 28.57 %.There was significant difference in the total effective rate between the two groups(P<0.01).5.Comparison of the effective rate of TCM symptom scores after treatment : 29 cases in the treatment group,25 cases were markedly effective after treatment,4 cases were effective,0 cases were ineffective,the total effective rate was 100 %,and the effective rate was 86.21 %.In the control group of 28 cases,after treatment,0 cases were markedly effective,8 cases were effective,20 cases were ineffective,and the total effective rate was 28.57 %.There was a statistically significant difference in the effective rate of TCM symptom scores between the two groups(P< 0.01).Conclusion: The combination of Jiangqi Xiaoying Decoction and western medicine can better improve the repeated attack of patients with refractory hyperthyroidism,and has a better control effect on the titer of thyrotropin receptor antibody.It has a significant effect on improving the clinical symptoms of patients,so as to better stabilize the patient ’s condition and reduce the probability of recurrence.It has good clinical efficacy and is worthy of further research and promotion.