Clinical Study Of Jiedu Xiaoji Prescription Combined With EP Regimen In The Treatment Of Extensive Small Cell Lung Cancer

Objective: To compare the clinical efficacy of Jiedu Xiaoji prescription combined with EP regimen(etoposide + cisplatin)and EP regimen alone in the treatment of extensive small-cell lung cancer(SCLC).Objective data analysis was conducted in order to obtain objective scientific basis for clinical benefits,and the advantages of Jiedu Xiaoji prescription combined with conventional chemotherapy for extensive small-cell lung cancer(ED-SCLC)were discussed,so as to explore the objective advantages of traditional Chinese medicine in treating ED-SCLC.Methods: According to diagnostic criteria and exclusion criteria,60 patients with ED-SCLC were selected and randomly divided into control group and test group using random number table method by referring to the sample content estimation formula required for the comparison of two sample rates in the fourth edition of Medical Statistics.Control group was treated with conventional chemotherapy,and experimental group was treated with conventional chemotherapy combined with Jiedu Xiaoji prescription of traditional Chinese medicine decoction,starting 1 day before each cycle of chemotherapy,for 14 consecutive days.The patients were treated for three consecutive cycles of chemotherapy.During the observation period,shedding and elimination were performed according to shedding and elimination criteria if there were any changes in the condition.Then,the therapeutic efficacy,toxicity and side effects of the two groups of patients were compared according to the efficacy evaluation index and safety index.Content:A total of 60 inpatients with ED-SCLC from November 2021 to November2022 were enrolled and divided into test group and control group,which were treated with EP regimen + conventional symptomatic treatment(control group),Jiedu Xiaoji prescription +EP regimen + conventional symptomatic treatment(experimental group),respectively.After 3 cycles of treatment,the therapeutic efficacy of solid tumor,the efficacy of traditional Chinese medicine syndrome,the Cartesal score of quality of life,chemotherapy related toxicity and side effects were statistically compared between the two groups.Results:There was no significant difference in age,gender,smoking status and other baseline characteristics between the treatment group and the control group.The results showed that the effective rate(ORR)of the experimental group was 37.93% and the control rate(DCR)was 89.66%,while the effective rate(ORR)of the control group was 31.03% and the control rate(DCR)was 86.21%.The results showed that the effective rate and control rate of the experimental group were higher than that of the control group,and the treatment effect of the experimental group was better,but there was no significant difference between the two by statistical analysis.After treatment,the level of tumor marker NSE in experimental group decreased significantly compared with control group,and the difference was statistically significant(P < 0.05),but there was no significant difference in CEA level between the two groups after treatment.In terms of TCM syndrome score,after treatment,experimental group was significantly decreased compared with control group(P < 0.05).In terms of TCM clinical syndromes,the effective rate of the experimental group was 89.66% after treatment,and that of the control group was 55.17%.The experimental group had better effect than the control group.The difference was statistically significant(P <0.05).After treatment,KPS scores of the experimental group and the control group were not significantly increased,and there was no statistical difference.In terms of effective rate,the effective rate of the experimental group was 82.76%,and that of the control group was 75.86%.The effective rate of the experimental group was higher than that of the control group,but after statistical analysis,P> 0.05,the difference was not statistically significant.Statistical tests and studies were conducted to compare the incidence of leukocyte level reduction,pulmonary symptoms,fever and constipation after treatment between the two groups,and it was found that there was no statistical significance between the two groups.Conclusion:Jiedu Xiaoji prescription combined with EP regimen in the treatment of ED-SCLC can not only reduce the level of tumor marker NSE in patients,but also have certain advantages in relieving the discomfort symptoms of patients.