| Background and objective:Alzheimer’s disease(AD)is a neurodegenerative disease commonly seen in the elderly,clinically characterized by cognitive impairment,accompanied by psychobehavioral abnormalities and social life dysfunction.Alzheimer’s disease has not only seriously reduced the quality of life of patients and their families,but also caused serious economic burden to the society.Because the etiology of Alzheimer’s disease is unknown,the onset is insidious,and no specific drugs have been successfully developed,the early detection and intervention of Alzheimer’s disease is very important.Mild cognitive impairment(MCI)and mild behavioral impairment(MBI)are cognitive impairment and neuropsychiatric symptoms that may occur in the elderly without dementia.Follow-up studies show that the risk of dementia will be increased if both functional impairments occur at the same time.Alzheimer’s disease-related neurofilament protein(AD7c-NTP)is a neurofilament protein related to neuronal degeneration,which is expressed in the whole course of Alzheimer’s disease and in the cerebrospinal fluid and urine of patients with MCI.Its expression level is related to the degree of cognitive impairment of patients,and is considered as a potential biomarker of Alzheimer’s disease.The non-invasive,convenient and low-cost nature of urine detection makes the detection of AD7c-NTP content in urine have the potential to be used in Alzheimer’s disease screening and clinical promotion.However,how the urine AD7c-NTP level of MBI patients is expressed is not clear.This study attempts to explore the effect of MCI and MBI on the urine AD7c-NTP level of the elderly by evaluating the cognitive function and psychobehavioral function of the elderly and combining with the urine AD7cNTP level detection,so as to provide some reference for the early detection of Alzheimer’s disease.Materials and methods:select from January 2022 to December 2022 Dalian Seventh people’s Hospital A total of 116 outpatients,inpatients,and volunteers without cognitive and behavioral disorders recruited from the elderly in the community or general hospitals in the same region during the same period were divided into four groups according to the scores of MoCA and MBI-C scales.Their general data were obtained by questionnaires or medical records,and their morning urine was collected for AD7c-NTP content detection.By analyzing the general data of different groups of patients and the level of AD7c-NTP in urine,to explore the effect of MCI and/or MBI on the level of AD7c-NTP in urine and the value of early detection of Alzheimer’s disease.Results:1.There were 32 patients with MBI complicated with MCI(group A),33 patients with MBI(group B),23 patients with MCI(group C)and 28 normal controls(group N).two。.Compared with the control group,there were significant differences in the age of group An and group B(P<0.01),the years of education in group A(P<0.01),and the age of first episode in group B(P<0.05).3.Compared with N group,MoCA score of group An and C,MBI-C score of group An and B,and FAQ score of group A were significantly different from those of group N(P<0.05).4.Compared with group N,the level of urinary AD7c-NTP in group An and group C was significantly different.The urinary AD7c-NTP level of 4.116 subjects was negatively correlated with MoCA score(r=0.59,P<0.01),and positively correlated with FAQ score(r=0.38,P<0.01).Conclusion:1.Mental and behavioral symptoms may appear earlier than cognitive symptoms in the elderly;2.The elderly with advanced age and low education are more likely to be complicated with mental and behavioral symptoms and cognitive symptoms.The level of urinary AD7c-NTP in the elderly is related to the degree of impairment of cognitive function and activities of daily living,and the correlation with the degree of mental and behavioral impairment needs to be further studied. |
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