Data Mining-based Study On The Dosage Pattern Of Dialectical Treatment Of Ulcerative Colitis In Chinese Medicine

Objective: Ulcerative colitis(UC)is one of the major types of inflammatory bowel disease(IBD),and the treatment of this disease is still very challenging.In this paper,we collected the clinical research literature on the treatment of UC in Chinese medicine published in CNKI and Wanfang in the past 10 years,analyzed the data of Chinese medicine in the literature,derived the rules of Chinese medicine in the treatment of UC,summarized the current treatment status,and actively explored the new methods and new ways of Chinese medicine treatment of UC,hoping to provide some experience reference for the treatment of UC in Chinese medicine in the future.We hope to provide some experience for the future treatment of UC with TCM.Methods: The clinical research literature published in China Knowledge Network and Wanfang from January 2010 to January 2022 regarding the treatment of UC in Chinese medicine was searched,and the included literature was finalized by manual search according to the set inclusion and exclusion criteria.In this study,203 literature articles were selected and 205 prescriptions were obtained.The data of the final included literature were collated,and the distribution of evidence types and the disease location and nature of the evidence types were summarized using Microsoft Excel 2019,and a Chinese medicine database was established.With the aid of the TCM heritage assistance platform,the frequency,efficacy,four qi and five tastes,the attribution of meridians and the high-frequency use of Chinese medicine in the treatment of ulcerative colitis,the The statistical analysis of drug association rules and clustering results was conducted.Results:1.The evidence types included in the literature were summarized,involving 28 evidence types,of which 18 were related to "spleen deficiency" and 11 to "damp-heat".The top 6 evidence types in terms of frequency were Damp-Heat in the Large Intestine,Yang Deficiency in the Spleen and Kidney,Dampness in the Spleen,Liver Deficiency in the Spleen,Damp-Heat in the Spleen,and Mixed Cold-Heat,with the pathological elements of Spleen,Large Intestine,Liver and Kidney and the pathological elements of Dampness,Heat,Deficiency,Cold,Heat Poison,Qi Stagnation and Blood Stasis.2.197 Chinese herbal medicines were counted in this study;the total frequency of occurrence of all Chinese medicines was 2420;the 10 most frequently used herbs were: Glycyrrhiza glabra,Atractylodes macrocephala,Huang Lian,Poria,Dang Shen,Bai Shao,Mu Xiang,Angelica sinensis,Huang Qi and Chen Pi.3.The top 5 herbs ranked by efficacy in this study were: tonifying deficiency,clearing heat,regulating qi,stopping bleeding,and inducing diuresis.4.four qi and five tastes: four qi: the medicinal properties are mainly warm,cold and flat,with warm medicines being the most used and cold medicines the second.The five tastes: bitter medicines are the most used,followed by sweet and pungent.5.In terms of attribution to the spleen meridian: most often to the spleen meridian,followed by the stomach and liver meridians.6.From the clustering results: the use of high-frequency herbs was clustered into 6 categories,the first category: Bai Zhu,Gan Cao,Fu Ling,Shan Yao,Chen Pi,Dang Shen,Sha Ren,Bai Lentil.The second category:Glycyrrhiza glabra,Atractylodes macrocephala,Nutmeg,Boneset,Poria,Radix Codonopsis,Radix et Rhizoma Huanglian,Radix Paeoniae Alba.Class III: Glycyrrhiza glabra,Rhizoma Atractylodis Macrocephalae,Atractylodes Macrocephalae,Radix Panax Ginseng,Radix Paeoniae Alba,Radix Paeoniae Alba,Radix Ginger.Class IV: Glycyrrhiza glabra,Huang Lian,Scutellaria baicalensis,Radix Angelicae Sinensis,Radix Paeonia lactiflora,Mucuna pruriens,Radix et Rhizoma gastrodiae,Radix Codonopsis pilosulae.Class V:Atractylodes Macrocephala,Radix et Rhizoma Huanglian,Radix Astragali,Poria,Radix Paeoniae Alba,Radix Glycyrrhiza Uralensis,Radix Angelicae Sinensis,Radix Mucuna Pruriens.Class VI: Glycyrrhiza glabra,Atractylodes macrocephala,Rhizoma Atractylodis Macrocephala,Radix Angelicae Sinensis,Radix Angelicae Sinensis,Poria Cocos,Radix Paeoniae Alba.7.from the rules of association: the common drug combinations are those that strengthen the spleen,benefit Qi,and clear heat and dampness.11 groups are composed of Poria,Dang Shen → Bai Zhu;Dang Shen → Bai Zhu;Poria → Bai Zhu;Gan Cao,Poria → Bai Zhu;Gan Cao,Dang Shen→ Bai Zhu;Huang Lian,Poria → Bai Zhu;Mu Xiang → Huang Lian;Huang Scutellaria → Gan Cao;Chen Pi → Bai Zhu;Bai Zhu,Mu Xiang→ Huang Lian;Gan Cao,Mu Xiang → Huang Lian.Conclusion(s):1.The types of evidence included in this institute are mainly large intestine humid heat evidence,spleen and kidney yang deficiency evidence,spleen deficiency and dampness evidence,liver depression and spleen deficiency evidence,spleen deficiency humid heat evidence,cold and heat miscellaneous evidence and other evidence types,the disease position evidence is mainly spleen,large intestine,kidney,liver,etc.,and the disease evidence is mainly humidity,heat,deficiency,etc.2.Deficiency supplementation,heat clearing,qi management,hemostasis,water seepage and moisture are the most used,and the pathogenesis of UC can be obtained: ulcerative colitis patients often have positive deficiency,mixed with heat,qi stagnation,bleeding,wet evil,etc.3.Among the commonly used drugs for the treatment of ulcerative colitis,the medicinal properties are mainly warm,cold and flat;The medicinal taste is mainly bitter,sweet and spicy;The spleen meridian,stomach meridian and liver meridian are the main ones.4.In cluster analysis,it can be found that Sijunzi Soup,Samling Baishusan,Si Shen Pill and other prescriptions are often used to treat UC.5.In the association analysis,most of them are drug combinations that strengthen the spleen and invigorate qi,clear heat and moisture.The 11 groups were composed of Zhu Ling,Party Ginseng → Baishu;Party ginseng → white art;Poria → albican;Licorice,poria → albicana;licorice,codonopsis → albican;Coptis lian,Poria → albican;woody incense→Coptis;Skullcap→licorice;Tangerine peel→white art;Baishu,woody→huanglian;Licorice,woody→Coptis.