Discussion On The Medication Law Of Traditional Chinese Medicine In The Treatment Of Ulcerative Colitis Based On Data Mining

Objective: This study uses the modern network data mining method,and takes the TCM prescriptions in the clinical controlled research experimental literature as the research object,and uses SPSS 23 and SPSS Modeler 18 software to sort out,analyze and discuss the dialectical thinking and medication rules of traditional Chinese medicine in the treatment of UC.Potential new prescriptions uncovered can provide reference for clinical Chinese medicine diagnosis and treatment of UC.Methods: Searched CNKI from January 2015 to January 2021 on the clinical controlled trials of traditional Chinese medicine in the treatment of UC,then extracted information such as syndrome types,disease syndrome elements,and traditional Chinese medicine prescriptions from the literatures,and used Excel 2013 to establish a corresponding database and normalized the datas,and Excel 2013 software was used for frequency analysis,SPSS Modeler 18.0 software was used for association rule analysis,and SPSS Statistics 23.0 software was used for cluster analysis,in order to explore the medication rules of traditional Chinese medicine in the treatment of UC.Results: From the retrieved 1373 literatures,121 literatures were screened,121 prescriptions were included,involving 17 syndrome types,including 6 syndrome types involving "spleen deficiency" and 5 syndrome types involving "damp heat";There were 171 flavors traditional Chinese medicine,which were divided into 17 categories according to their efficacy,and the total frequency of traditional Chinese medicine used was 1360 times.The top 5 types of syndrome frequency were: damp-heat internal type（22 times）,large intestine damp-heat type（21times）,spleen-kidney-yang deficiency type（15 times）,spleen-deficiency damp accumulating type（11 times）,spleen-deficiency damp-heat type（10 times）,the disease location elements of the syndrome type were spleen（48 times）,large intestine（22 times）,kidney（15 times）,liver（8 times）,and the disease elements of the syndrome type were dampness（67times）,heat（65 times）,deficiency（58 times）,blood stasis（11 times）,cold（6 times）,turbid poison（4 times）,heat poison（3 times）,phlegm（1 time）.The top 20 most frequently used were Licorice,Atractylodes,Rhizoma Coptidis,Muxiang,Paeonia lactiflora,Poria,Codonopsis,Angelica,Coix Seed,Scutellaria,Pulsatilla,Astragalus,pericarpium citri reticulatae,Treats,Pueraria,cortex fraxini,Fangfeng,Burnet,Yam,Red Peony.The top 10 types of drugs used were tonic（27 flavors,401 times）,heat-clearing drugs（31 flavors,303times）,qi-regulating drugs（10 flavors,125 times）,and hemostatic drugs（17 flavors,105 times）,diuresis and dampness medicine（10 flavors,102 times）,astringent medicine（16 flavors,74 times）,diaphoretic medicine（10 flavors,74times）,warming medicine（6 flavors,47 times）,blood-activating and stasis-removing medicine（17 flavors,42times）,herbs for dampness（6 flavors,34 times）.The spleen（24%）,stomach（16%）,liver（13%）,lung（12%）and large intestine meridian（10%）were the main meridians of the selected prescriptions,and The four qi were mainly warm（35%）,cold（27%）,and flat（27%）,and the five flavors were mainly bitter（33%）,sweet（29%）,acrid（20%）,and sour（9%）.The action and efficacy of the drug were mainly tonic,clearing heat,regulating qi,and hemostasis.The minimum conditional support was set to be 10%,the minimum rule confidence was set to be90%,and the maximum number of preceding items was 2,then the association rule results were obtained: 10 drug pair association rules and 42 3-drug combination association rules.On the basis of the frequency statistics,this study used SPSS22.0 software to perform systematic cluster analysis on the top 28 drugs whose using frequency exceeded 10% of the total frequency,and obtained 4 clustering results,namely:Pulsatilla – Qinpi-Treats-Pueraria-Burnet-sage grass-Purslane-Red peony（damp-heat brewing toxin syndrome）,Licorice-Dried Ginger-Angelica-Cinnamon-Paeoniae Alba-Muxiang-Betel Nut-Coptidis-Scutellaria（yang deficiency and damp heat syndrome）,pericarpium citri reticulatae-Fangfeng-Atractylodes-Poria-Codonopsis-Coix seed-Chinese yam（Spleen deficiency and dampness syndrome）,Bletilla hyacinthina Reichb-Panax notoginseng-Agrimony-Astragalus（Qi deficiency and blood stasis syndrome）.Conclusions: From the above research results,it can be concluded that UC is rooted in spleen deficiency,and its pathogenesis is that various factors such as feeling exogenous pathogens,improper diet,emotional insufficiency and other factors lead to weakness of the spleen and stomach,then dampness pathogens engendering and stagnating for a long time to produce heat,or wind pathogens carrying heat entering the interior,heat and humidity brewing into poison over time,burning the intestinal mucosa,qi and blood stagnating,eventually causing flesh to rot to form ulcers.The treatment of UC should be mainly based on Nourishing deficiency and strengthening the spleen,clearing heat and drying dampness,regulating qi stagnation,stanching bleeding,promoting diuresis,converging intestines to stop diarrhea.The four new prescriptions obtained in this study provide theoretical reference for the corresponding prescriptions for UC of damp-heat brewing toxin,yang deficiency damp heat,spleen deficiency dampness accumulating,qi deficiency and blood stasis.