Clinical Study On The Correlation Of Hypertension Inflammatory Factors With Blood Pressure Reaching Standards,arteriosclerosis And The Intervention Of Zhuang Medicine Santeng Yangxin Tongmai Fang

Objective: Hypertension is a common disease and frequently-occurring disease of the cardiovascular system.It is affected by many people all over the world.Hypertension is a type of vascular inflammation that has been widely confirmed by research.Vascular lesions provide the pathological basis.This study is to verify the correlation between inflammatory factors in patients with Qi deficiency and blood stasis hypertension and whether blood pressure can reach the standard and the degree of arteriosclerosis,and to understand whether Zhuang medicine Santeng Yangxin Tongmai Decoction can improve Qi deficiency and blood stasis type The efficacy of TCM syndromes,blood pressure,arteriosclerosis and lowering the level of related inflammatory factors in patients with hypertension.Methods: 1.Clinical verification: Select 60 cases of hypertension patients with Qi deficiency and blood stasis type who were admitted to the hospital from September 2019 to April 2020,and the blood pressure did not meet the standard(systolic blood pressure ≥140mm Hg and/or diastolic blood pressure ≥90mm Hg)30 The blood pressure was not up to the standard group,and 30 patients whose blood pressure was up to the standard(systolic blood pressure <140mm Hg and diastolic blood pressure <90mm Hg)were the blood pressure up-to-standard group.Collect baseline data such as gender,age,and TCM syndrome scores of all patients.Test the patient’s:(1)Blood pressure:All subjects should be at rest and rest for at least 5 minutes with an upper-arm medical electronic sphygmomanometer to measure the blood pressure of the right upper arm in the morning;(2)Inflammatory factor: Interleukin-6(Interleukin-6)IL-6),tumor necrosis factor-a(Tumor necrosis factor-a TNF-a),intercellular adhesion molecule-1(ICAM-1);(3)atherosclerosis index:ankle-brachial index(Ankle-brachial index ABI),Brachial ankle pulse wave velocity ba PWV.To understand the differences between the two groups in blood pressure,TCM syndrome integral,inflammatory factors and arteriosclerosis indexes,and the correlation between the levels of related inflammatory factors and blood pressure and arteriosclerosis indexes.2.Clinical treatment: 30 patients with qi deficiency and blood stasis type hypertension whose blood pressure did not reach the standard in clinical verification were taken as the treatment group,and 30 patients with qi deficiency and blood stasis type hypertension whose blood pressure did not meet the standard were included as the control group.Before treatment,there was no statistically significant difference in gender,age,total score of TCM syndromes,blood pressure,inflammatory factor levels,and arteriosclerosis between the two groups of patients.The control group was given amlodipine besylate tablets,the starting dose was 5 mg orally once a day,the dose was adjusted according to the blood pressure level,and the blood pressure reached the target as the treatment goal.In the treatment group,on the basis of amlodipine besylate tablets,the Zhuang drug Santo Yangxin Tongmai Recipe was added,one dose a day,decoction in water,and divided into morning and evening.The course of treatment was 12 weeks.Any adverse reactions were recorded.After 12 weeks,the same method was used to detect the scores of TCM syndromes,blood pressure,inflammatory factors,and arteriosclerosis indicators of the two groups of patients,and compare the differences between the two groups after treatment.Results: Clinical verification: 1.There was no statistically significant difference in gender and age between the blood pressure failure group and the blood pressure compliance group(P>0.05).The blood pressure substandard group was higher than the blood pressure standard group in the total score of TCM syndromes,blood pressure,inflammatory factors(IL-6,TNF-a,ICAM-1)and arteriosclerosis indicators(ABI,ba PWV),and the difference was statistically significant(P<0.05).2.The level of related inflammatory factors is positively correlated with blood pressure and arteriosclerosis indexes through correlation analysis.Clinical treatment: 1.Before treatment,the treatment group and the control group(re-enrolled hypertensive patients with Qi deficiency and blood stasis type whose blood pressure is not up to the standard),the two groups are based on gender,age,total score of TCM syndromes,blood pressure,inflammatory factors(IL-6,TNF-a,ICAM-1)and arteriosclerosis indexes(ABI,ba PWV),the difference was not statistically significant(P>0.05),and the two groups were comparable.2.After treatment,the total score of TCM syndromes,blood pressure,inflammatory factors(IL-6,TNF-a,ICAM-1)and arteriosclerosis indexes(ABI,ba PWV)of the treatment group were lower than those of the control group,and the difference was statistically significant.Academic significance(P<0.05).Conclusions: 1.Among the people with Qi deficiency and blood stasis hypertension and blood pressure that do not meet the standard,the total scores of TCM syndromes,the level of inflammatory factors and the degree of arteriosclerosis are higher than those of the hypertension with Qi deficiency and blood stasis.2.The levels of inflammatory factors in patients with Qi deficiency and blood stasis hypertension are positively correlated with blood pressure and arteriosclerosis.3.The increase of inflammatory factors is not conducive to the blood pressure of hypertensive patients with Qi deficiency and blood stasis.4.Zhuang medicine Santoyang Xintongmai prescription combined with amlodipine besylate tablets can improve Qi better than amlodipine besylate tablets.TCM syndromes,blood pressure,degree of arteriosclerosis and inflammation in patients with hypertension of deficiency and blood stasis Symptom factor level.